复方中药配伍现代减肥成分的动物实验研究  

Animal Experiments of the Efficacy of Modern Weight Loss Ingredients in Combination with Traditional Chinese Medicine

作　　者：李亚梅 郑晓杰[1] 孙明哲 胡奇[2] 李晓燕[1] LI Yamei;ZHENG Xiaojie;SUN Mingzhe;HU Qi;LI Xiaoyan(Shijiazhuang Yiling Pharmaceutical Co.,Ltd.,Shijiazhuang 050035,China;Health Analysis and Testing Center,Nanjing Medical University,Nanjing 211166,China)

机构地区：[1]石家庄以岭药业股份有限公司,河北石家庄050035 [2]南京医科大学卫生分析检测中心,江苏南京211166

出　　处：《生物化工》2024年第5期119-123,共5页Biological Chemical Engineering

摘　　要：目的:探讨姜黄、决明子等复方中药提取物配伍左旋肉碱酒石酸盐和白芸豆提取物的减肥作用。方法:选用SD健康雄性大鼠为研究对象,建立肥胖大鼠模型,用姜黄、决明子等复方中药提取物配伍左旋肉碱酒石酸盐和白芸豆提取物进行减肥作用研究。大鼠随机分为空白对照组、模型对照组及4个配方试验组,观察各组大鼠的摄食情况、食物利用率、体质量变化及体内脂肪积累情况。结果:各试验组摄食量、总摄食量及摄入总热量与模型对照组比较无差异,试验组1、2、4体质量增长量和总质量增长量均低于模型对照组,试验组1和试验组4食物利用率和总食物利用率均低于模型对照组,试验组1和试验组4大鼠的睾丸及肾周围脂肪质量低于模型对照组,差异有统计学意义(p<0.05)。结论:该实验条件下,试验组1和4具有减肥作用。Objective:Exploring the weight loss effects of compound Chinese medicine extracts such as Curcuma longa L.and Cassia obtusifolia L.combined with L-carnitine-L-Tartrate and extracts of Phaseolus coccineus L..Methods:Using SD healthy male rats as the research object,fed with high calorie feed,establishing an obese rat model.Study on the weight loss effect of compound Chinese medicine extracts with L-carnitine-L-Tartrate and extracts of Phaseolus coccineus L..Rats are randomly divide into a blank group,a model group,and four formula experimental groups.The feeding status,food utilization rate,weight gain,and body fat weight of rats are observed.Results:There is no difference in food intake,total food intake,and total calorie intake between the experimental groups and the model group.The weight gain and total weight gain of experimental groups 1,2,and 4 are lower than those model group.The food utilization rate and total food utilization rate of experimental groups 1 and 4 are lower than those of the model group.The testicular and perirenal fat weight of experimental groups 1 and 4 rats are lower than those model group.All the difference is statistically significant(p<0.05).Conclusion:Under this experimental condition,experimental groups 1 and 4 have a weight loss effect.

关 键 词：姜黄 决明子 左旋肉碱酒石酸盐 白芸豆提取物 肥胖 减肥 

分 类 号：R589.2[医药卫生—内分泌]