新冠疫情前后南京市某三甲医院儿童感染肺炎支原体的情况分析  

Analysis of Mycoplasma pneumoniae infection in children in a tertiary hospital of Nanjing before and after the COVID-19 outbreak

作　　者：何芳[1] 张晓阳 徐卫平[1] 郭一迪[1] 张国英[1] HE Fang;ZHANG Xiaoyang;XU Weiping;GUO Yidi;ZHANG Guoying(Department of Laboratory Medicine,Nanjing Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Nanjing University of Chinese Medicine,Nanjing 210014,Jiangsu,China)

机构地区：[1]南京中医药大学附属南京市中西医结合医院检验科,南京210014

出　　处：《临床检验杂志》2024年第11期873-876,共4页Chinese Journal of Clinical Laboratory Science

基　　金：南京市医学科技发展重点项目(ZKX22057)。

摘　　要：目的分析南京市中西医结合医院新冠疫情前后儿童感染肺炎支原体(Mycoplasma pneumoniae,MP)的流行病学特征,为MP感染防控诊治提供实验依据。方法回顾性分析南京市中西医结合医院2019—2023年因呼吸道感染就诊的17976例儿童,利用直接发光免疫法检测患儿血清特异性MP-IgM的表达水平,采用卡方检验分析新冠疫情前后不同性别、不同季节、不同年龄患儿中MP-IgM的检出率,初步探讨MP的流行病学特征。结果17976例呼吸道感染患儿血清MP-IgM总检出率为28.45%(5114/17976),其中女性患儿血清MP-IgM总检出率[31.69%(2672/8432)]明显高于男性患儿[25.59%(2442/9544)],差异有统计学意义(χ^(2)=81.89,P<0.001)。血清MP-IgM检出率在2019年时最高[34.35%(1415/4119)],随后依次为(2020—2022年)的22.03%(1290/5856)、2023年的30.11%(2409/8001),差异有统计学意义(χ^(2)=199.95,P<0.001)。秋季血清MP-IgM检出率最高,为33.16%(1683/5075),随后依次为夏季[28.61%(1053/3681)]、冬季[27.65%(1826/6604)]、春季[21.10%(552/2616)],差异有统计学意义(χ^(2)=126.90,P<0.001)。各年龄组中,7~9岁段患儿血清MP-IgM检出率最高[35.83%(1190/3321)],随后依次为4~6岁[28.06%(1882/6707)]、1~3岁[26.55%(1493/5623)]、10~18岁段[23.64%(486/2056)]和<1岁[23.42%(63/269)],各组间差异有统计学意义(χ^(2)=126.11,P<0.001)。结论MP是儿童呼吸道感染的常见病原体,尤其是7~9岁年龄段,其中女性患儿高于男性患儿,秋季发病高峰期;疫情有效的防控措施降低了MP-IgM的检出率,可为MP感染传播及其他呼吸道疾病的控制及预防提供一定的实验依据。Objective To investigate the epidemiological characteristics of Mycoplasma pneumoniae(MP)infection in children in Nanjing Integrated Traditional Chinese and Western Medicine Hospital before and after the COVID-19 outbreak,and provide an experimental basis for the prevention and treatment of MP infection.Methods The clinical data of 17976 children visited Nanjing Integrated Traditional Chinese and Western Medicine Hospital from January 2019 to November 2023 due to respiratory tract infections were retrospectively analyzed.The levels of serum specific MP-IgM in the children were detected by the direct luminescence immunoassay,and the detection rates of MP-IgM in different genders,seasons,and ages before and after the COVID-19 epidemic were analyzed using the chi square test to explore the epidemiological characteristics of MP infection.Results The total detection rate of serum MP-IgM in 17976 children with respiratory tract infections was 28.45%(5114/17976).Among them,the total detection rate of serum MP-IgM in female children(31.69%,2672/8432)was significantly higher than that in male children(25.59%,2442/9544,χ^(2)=81.89,P<0.001).The detection rate of serum MP-IgM was highest in 2019(34.35%,1415/4119),followed by in 2023(30.11%,2409/8001)and in 2020-2022(22.03%,1290/5856),with statistically significant difference(χ^(2)=19.95,P<0.001).The detection rate of serum MP-IgM was highest in autumn(33.16%,1683/5075),followed by in summer(28.61%,1053/3681),winter(27.65%,1826/6604),and spring(21.10%,552/2616),with statistically significant difference(χ^(2)=126.90,P<0.001).Among different age groups,the detection rate of serum MP-IgM was highest in the age group of 7-9 years old(35.83%,1190/3321),followed by 4-6 years old(28.06%,1882/6707),1-3 years old(26.55%,1493/5623),10-18 years old(23.64%,486/2056),and<1 year old(23.42%,63/269),with statistically significant difference(χ^(2)=126.11,P<0.001).Conclusion MP is a common pathogen of respiratory tract infections in children,especially in the age range of 7-9 years old,wit

关 键 词：肺炎支原体 呼吸道感染 儿童 新冠疫情 

分 类 号：R446[医药卫生—诊断学]