聚己内酯/萘普生复合物的制备与性能研究  

Preparation and Properties of Polycaprolactone/Naproxen Composites by Electrospraying

作　　者：李席 李红 王亚 龚梦园 丁佳豪 周密[1,2] 王若宇 方孝斌 Li Xi;Li Hong;Wang Ya;Gong Mengyuan;Ding Jiahao;Zhou Mi;Wang Ruoyu;Fang Xiaobin(Functional Powder Material Laboratory of Bengbu City,Bengbu University,Bengbu,Anhui 233030,China;Anhui Xiangyuan Technology Co.,Ltd.Bengbu,Anhui233030,China)

机构地区：[1]蚌埠学院功能粉体材料蚌埠市实验室,安徽蚌埠233030 [2]安徽祥源科技股份有限公司,安徽蚌埠233030

出　　处：《湖北工程学院学报》2024年第6期11-16,共6页Journal of Hubei Engineering University

基　　金：安徽省高校自然科学研究重点项目(2023AH052944);国家级大学生创新创业训练计划项目(202311305061);蚌埠学院大学生创新创业训练计划项目(2024024,2024083,2024046);蚌埠学院科学研究项目(2024YYX48QD,2024YYX36pj)。

摘　　要：以聚己内酯(PCL)为载体材料,萘普生(NPX)为模型药物,使用静电喷雾技术制备PCL/NPX复合物,利用扫描电镜(SEM)、X射线衍射仪(XRD)、差示扫描量热仪(DSC)、红外光谱仪(FITR)、热重分析仪(TG)和紫外可见分光光度计分析了复合物形貌、结构和性能。结果表明,PCL/NPX复合物微球表面光滑,粒径在1~5μm,粒度分布较窄,NPX添加量(5%~10%)对PCL/NPX复合物微球粒径无显著影响,NPX以无定型态分散在PCL中,化学组成未有变化,稳定性较纯NPX显著提高。PCL/NPX复合物中NPX的释放速率和累计释放量随NPX投药量的增加而降低,含5%NPX的PCL/NPX复合物在24h内累计释放量可达77.5%。静电喷雾法制备的PCL/NPX复合物有望为NPX缓释剂的研发提供重要参考。Naproxen-loaded polycaprolactonecomposites were successfully designed by electrospraying used polycaprolactone(PCL)as carrier material and Naproxen(NPX)as model drug.The morphology,structure and properties of PCL/NPX composites were analyzed by scanning electron microscope(SEM),X ray diffractometer(XRD),infrared spectrophotometer(FITR),differential scanning calorimetry(DSC),thermogravimetric analyzer(TG)and UV-Vis spectrophotometer.Results showed that the PCL/NPX composites showed smooth surface with diameter between 1~5μm and narrow particle size distribution.NPX was loaded in PCL with amorphous state,and the chemical composition was unchanged.The thermal stability of PCL/NPX composites was significantly improved than that of pure NPX.With the increase content of NPX,the release rate and cumulative release amount of NPX from PCL/NPX composites decreased.The cumulative release amount of NPX from PCL/NPX composites reached 77.5%at the end of 24h when the NPX content added to 10%.The PCL/NPX composites prepared by electrospraying method are expected to provide valuable reference for the research and development of sustained-release agents.

关 键 词：静电喷雾 聚己内酯 萘普生 无定形 性能 

分 类 号：TQ352[化学工程]