新型冠状病毒感染老年病人病情影响因素的Meta分析  

Influencing factors of COVID-19 in the elderly patients:a Meta-analysis

作　　者：李珊珊 贺生 范瑾 许明珠 LI Shanshan;HE Sheng;FAN Jin;XU Mingzhu(Sichuan Nursing Vocational College,Sichuan 610000 China)

机构地区：[1]四川护理职业学院,四川610000

出　　处：《循证护理》2024年第23期4187-4191,共5页Chinese Evidence-Based Nursing

基　　金：四川护理职业学院基金资助自然科学一般课题,编号:2022RZY25。

摘　　要：目的:探讨新型冠状病毒感染(COVID-19)老年病人病情的影响因素,以期及时干预,促进疾病好转,降低病死率。方法:检索中国知网、维普数据库、万方数据库、PubMed、the Cochrane Library、MedLine、EMbase等数据库中关于COVID-19老年病人影响因素的相关文献,检索时限为2019年12月—2022年12月。采用RevMan 5.3软件进行Meta分析。结果:纳入16篇文献,涉及2 883例病人,其中轻症2 141例,重症及危重症742例。COVID-19老年病人的影响因素共11项,包括年龄[OR=-1.59,95%CI(-2.48,-0.70)]、合并糖尿病[OR=1.55,95%CI(1.11,2.17)]、合并高血压[OR=1.66,95%CI(1.11,2.46)]、合并冠心病[OR=1.33,95%CI(1.06,1.66)]、合并慢性阻塞性肺疾病或其他肺部疾病[OR=1.75,95%CI(1.29,2.38)]、C反应蛋白(CRP)[OR=1.03,95%CI(1.01,1.04)]、乳酸脱氢酶(LDH)[OR=1.03,95%CI(1.02,1.04)]、D-二聚体[OR=1.01,95%CI(1.01,1.02)]、肌酸激酶[OR=1.09,95%CI(1.00,1.18)]、淋巴细胞绝对值[OR=0.08,95%CI(0.04,0.18)]、中性粒细胞与淋巴细胞比值(NLR)[OR=1.12,95%CI(1.04,1.21)],均P<0.05。结论:现有证据表明,年龄、合并糖尿病、合并高血压、合并冠心病、合并慢性阻塞性肺疾病或其他肺部疾病、CRP、LDH、D-二聚体、肌酸激酶、淋巴细胞绝对值、NLR均为COVID-19老年病人病情发展为重症的影响因素。临床上应高度重视相关影响因素,采取有效的干预措施,预防疾病恶化并降低死亡率。Objective:To explore the influencing factors of the condition of coronavirus disease(COVID-19)elderly patients in order to timely intervene,promote the improvement of the disease and reduce the mortality.Methods:Retrieved articles related to risk factors of the elderly patients with COVID-19 from CNKI,VIP,WanFang Database,PubMed,the Cochrane Library,MedLine,EMbase.The retrieval time was from December 2019 to December 2022.Used RevMan 5.3 software for Meta-analysis.Results:A total of 2883 patients were included in 16 articles,including 2141 mild cases and 742 severe and critical illness.There were 11 influencing factors affecting elderly patients with COVID-19,including age(OR=-1.59,95%CI-2.48--0.70),combined diabetes(OR=1.55,95%CI 1.11-2.17),combined hypertension(OR=1.66,95%CI 1.11-2.46),combined coronary heart disease(OR=1.33,95%CI 1.06-1.66),combined chronic obstructive pulmonary disease or other pulmonary diseases(OR=1.75,95%CI 1.29-2.38),C-reactive protein(CRP)(OR=1.03,95%CI 1.01-1.04),lactate dehydrogenase(LDH)(OR=1.03,95%CI 1.02-1.04),D-dimer(OR=1.01,95%CI 1.01-1.02),creatine kinase(OR=1.09,95%CI 1.00-1.18),lymphocyte absolute value(OR=0.08,95%CI 0.04-0.18),and neutrophil to lymphocytic ratio(NLR)(OR=1.12,95%CI 1.04-1.21),all P<0.05.Conclusion:Current evidence shows that age,combined diabetes,combined hypertension,combined coronary heart disease,combined chronic obstructive pulmonary disease or other lung diseases,CRP,LDH,D-dimer,creatine kinase,lymphocyte absolute value,NLR are all infleuncing factors for the elderly patients with COVID-19 to develop into severe disease.In clinical practice,high attention should be paid to relevant influencing factors,effective intervention measures should be taken to prevent disease deterioration and reduce mortality.

关 键 词：新型冠状病毒感染 老年人 影响因素 META分析 循证护理 

分 类 号：R473.5[医药卫生—护理学]