Tuning amino/hydroxyl ratios of nanovesicles to manipulate protein corona-mediated in vivo fate  

作　　者：Wenhao Wang Siyuan Peng Zhengwei Huang Xin Pan 

机构地区：[1]School of Pharmaceutical Science,Sun Yat-sen University,Guangzhou 510006,China [2]College of Pharmacy,Jinan University,Guangzhou 511443,China [3]State Key Laboratory of Bioactive Molecules and Druggability Assessment,Jinan University,Guangzhou 511443,China

出　　处：《Chinese Chemical Letters》2024年第11期3-5,共3页中国化学快报（英文版）

摘　　要：With the rapid advancement of nanotechnology,nanocarriers for drug delivery have created promising prospects for efficient drug administration and precise disease therapy.However,only a limited number of these nanocarriers were successfully processed into the clinic or market[1].The unclear fate of these nanocarriers when administrated in vivo is believed to be the one to blame.When nanocarriers are administrated in vivo,they will encounter complicated environmental factors including biomacromolecules,diversified p H,functional immune cells and hydromechanical forces,which might make the tracking of nanocarriers unpredictable.

关 键 词：VIVO PRECISE advancement 

分 类 号：R943[医药卫生—药剂学] TB383.1[医药卫生—药学]