DNA-based nanosystems to generate reactive oxygen species for nanomedicine  

作　　者：Zhongyu Wang Lijun Wang Huaixin Zhao 

机构地区：[1]Frontiers Science Center for Synthetic Biology,Key Laboratory of Systems Bioengineering(MOE),Institute of Biomolecular and Biomedical Engineering,School of Chemical Engineering and Technology,Tianjin University,Tianjin 300350,China

出　　处：《Chinese Chemical Letters》2024年第11期25-34,共10页中国化学快报（英文版）

基　　金：financial support provided by the National Key R&D Program of China(No.2022YFC2603800);the National Natural Science Foundation of China(No.22274113)。

摘　　要：Reactive oxygen species(ROS)are essential in various pathological and physiological processes.Developing nanosystems that generate ROS in a controlled manner is of great interest for nanomedicine.DNA nanotechnology offers a promising approach to constructing programmable ROS-generating platforms.By incorporating photosensitizers or metal ions,DNA nanostructures can be designed to produce ROS in a spatially and temporally desired fashion.DNA-based ROS-generating nanosystems hold great potential in intracellular homeostasis regulation,drug release,and cancer therapy.This review summarizes recent advances in developing DNA-based ROS-generating nanosystems,highlights their emerging biomedical applications,and discusses the opportunities and challenges for further applications.DNA nanotechnology provides a versatile toolkit to construct biocompatible ROS-generating platforms for next-generation nanomedicines.

关 键 词：DNA nanotechnology Photodynamic therapy Chemodynamic therapy Reactive oxygen species Nanomedicine 

分 类 号：R318[医药卫生—生物医学工程] TB383.1[医药卫生—基础医学]