Copper-catalyzed photoredox 1,4-amidocyanation of 1,3-enynes with N-amidopyridin-1-ium salts and TMSCN:Facile access toα-amido allenyl nitriles  

作　　者：Liangfeng Yang Liang Zeng Yanping Zhu Qiuan Wang Jinheng Li 

机构地区：[1]State Key Laboratory of Chemo/Biosensing and Chemometrics,Hunan University,Changsha 410082,China [2]State Key Laboratory Base of Eco-Chemical Engineering,College of Chemical Engineering,Qingdao University of Science and Technology,Qingdao 266042,China [3]School of Pharmacy,Key Laboratory of Molecular Pharmacology and Drug Evaluation,Ministry of Education,Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong,Yantai University,Yantai 264005,China [4]State Key Laboratory of Applied Organic Chemistry,Lanzhou University,Lanzhou 730000,China

出　　处：《Chinese Chemical Letters》2024年第11期344-348,共5页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(No.22271245)for the financial support;the Yantai“Double Hundred Plan”;the Talent Induction Program for Youth Innovation Teams in Colleges and Universities of Shan-dong Province。

摘　　要：A new 1,4-amidocyanation of 1,3-enynes with N-amidopyridin-1-ium salts and TMSCN using a copper and photoredox synergetic catalysis for producingα-amido allenyl nitriles is developed.Employing N-amidopyridin-1-ium salts as the amidyl radical precursors,the reaction enables the formation of two new bonds,one C(sp^(3))-N bond and one C(sp^(2))-C(sp)bond,in a single reaction step.This reaction represents a mild,general route to the construction of theα-amido allenyl nitrile architectures,which characterizes a broad scope,a good functional group compatibility and an excellent selectivity.

关 键 词：Copper Photoredox catalysis Amidocyanation N-(Sulfonamido)pyridin-1-ium salts 1 3-Enynes α-Sulfonamido allenyl nitriles 

分 类 号：O621.251[理学—有机化学]