LB膜技术在生物基材料领域的应用与研究进展  

Application and Research Progress of LB Film Technology in the Field of Bio-based Materials

作　　者：孔英俊[1] 张贵锋[1] KONG Yingjun;ZHANG Guifeng(State Key Laboratory of Biochemical Engineering,Institute of Process Engineering,Key Laboratory of Biopharmaceutical Preparation and Delivery,Chinese Academy of Sciences,Beijing 100190,China)

机构地区：[1]中国科学院过程工程研究所生化工程国家重点实验室中国科学院生物药制备与递送重点实验室,北京100190

出　　处：《中国生物工程杂志》2024年第10期82-88,共7页China Biotechnology

基　　金：国家重点研发计划(2021YFC2400804);北京市自然科学基金-昌平创新联合基金(L234070、L234021、L234071);北京市自然科学基金(2244105)资助项目。

摘　　要：LB膜(Langmuir-Blodgett film)技术是一种能够在分子层面精确控制薄膜组装的技术,在生物模拟、传感技术、材料科学和生物医学等多个领域应用十分广泛。在生物基材料方面,LB膜技术能够制备出单层或多层的超薄生物基材料膜,并能通过调节LB膜的组成来有效控制膜的物理化学性质,为构建具有特定功能和性能的生物基材料提供了强大的工具;在生物基材料改性方面,LB膜技术被用于改善材料表面性质和制备具有特殊功能的涂层,从而影响材料的生物相容性和功能性,满足特定的应用需求;在生物基材料界面相互作用方面,LB膜技术被用于构建检测特定生物标志物的高性能生物传感器和监测生物分子的相互作用。随着技术的进步和对生物基材料需求的增长,LB膜技术在未来生物基材料科学与技术中的应用潜力将持续扩大。Langmuir Blodgett(LB)film technology is a technique that can precisely control the assembly of thin films at the molecular level,and has a wide range of applications in various fields such as biological simulation,sensing technology,materials science and biomedical research.In terms of bio-based materials,LB film technology can produce single or multi-layer ultra-thin bio-based material films,and can effectively control the physical and chemical properties of the films by adjusting the composition of LB films,providing a powerful tool for constructing bio-based materials with specific functions and properties;in terms of bio-based material modification,LB film technology is used to improve the surface properties of materials and to produce coatings with special functions,thereby affecting the biocompatibility and functionality of materials and meeting specific application requirements;in terms of interface interactions between bio-based materials,LB film technology has been used to construct high-performance biosensors for detecting specific biomarkers and monitoring the interactions of biomolecules.As technology advances and the demand for bio-based materials increases,the potential applications of LB film technology in future bio-based material science and technology will continue to expand.

关 键 词：LB膜 生物基材料 材料制备 材料改性 界面相互作用 

分 类 号：Q819[生物学—生物工程]