静电喷雾聚乳酸-羟基乙酸共聚物载药微球及其医学应用  

Research and Application of Electrostatic Spray Poly(Lactic-co-glycolic Acid)Drug-loaded Microspheres in Medicine

作　　者：朱元苹 郭子岩 李风兰 ZHU Yuanping;GUO Ziyan;LI Fenglan(Shanxi Medical University School and Hospital of Stomatology,Shanxi Medical University,Taiyuan 030000,China)

机构地区：[1]山西医科大学口腔医学院口腔医院,太原030000

出　　处：《中国生物工程杂志》2024年第10期99-110,共12页China Biotechnology

摘　　要：静电喷雾聚乳酸-羟基乙酸共聚物(poly lactic-co-glycolic acid,PLGA)载药微球因其可控的粒径和形貌、有效的药物包封率、对药物生理活性具有保护作用等优势,在医药领域展示出了巨大的应用前景。微球的大小和形貌在药物装载和体内吸收利用方面具有不可忽视的影响。静电喷雾过程中,可以通过调控相关参数制备具有特定要求的载药微球。概述静电喷雾的基本原理,重点介绍静电喷雾相关参数对PLGA微球粒径和形貌的影响以及载药微球在生物医学方面的应用,以期为药物递送领域的研究提供参考。Electrostatically sprayed polylactic acid-glycolic acid(PLGA)copolymer drug-loaded microspheres have promising medical applications due to their controllable particle size and morphology,high drug encapsulation rate,and ability to protect drug activity.The size and shape of microspheres have a significant impact on drug loading and absorption in vivo.By adjusting relevant parameters during electrostatic spraying,drug-loaded microspheres with specific characteristics can be produced.This article provides a comprehensive overview of electrostatic spraying,focusing on how various parameters impact the particle size and morphology of PLGA microspheres.It also delves into the utilization of drug-loaded microspheres in biomedicine and highlights the key challenges in this field.The findings presented heve are intended to serve as a valuable reference for ongoing research.

关 键 词：静电喷雾 聚乳酸-羟基乙酸共聚物(PLGA) 载药微球 药物递送 

分 类 号：Q819[生物学—生物工程]