金属及其复合材料在糖尿病创面愈合中的应用  

Metals and Their Composites in Diabetic Wound Healing

作　　者：周亚娇 朱俊逸 ZHOU Yajiao;ZHU Junyi(The Second Affiliated Hospital Zhejiang University School of Medicine,Hangzhou 310009,China;Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University,Taizhou 317000,China)

机构地区：[1]浙江大学医学院附属第二医院,杭州310009 [2]浙江省台州医院,台州317000

出　　处：《中国生物工程杂志》2024年第10期111-122,共12页China Biotechnology

基　　金：台州市科学技术局科技计划项目(21ywa11)对本研究的资助。

摘　　要：糖尿病慢性创面目前仍然是临床和研究的一项巨大挑战。由于氧化应激和细菌感染的恶性循环,炎症反应过度以及血管生成受阻等原因,糖尿病伤口愈合过程受到干扰,易发展成慢性创面,但目前临床上的治疗手段效果欠佳。金属及其复合材料有望解决这些问题。目前,银(Ag)、铜(Cu)、锌(Zn)和金(Au)等金属作为纳米颗粒和金属有机框架等形态及其与生物材料(如壳聚糖、海藻酸钠、抗生素等)组合成的复合材料在糖尿病创面中的应用与研究十分广泛。金属及其复合材料可以抑制糖尿病伤口中常见的细菌菌株的生长和繁殖,包括革兰氏阳性菌和革兰氏阴性菌,并表现出优异的抗炎、抗氧化、抗菌和促血管生成特性,最终改善糖尿病伤口的愈合。综述金属及其复合材料在治疗糖尿病伤口愈合中的研究进展,阐述相关作用机制,并展望未来的临床应用与发展。Chronic wounds in diabetes remain a major clinical and research challenge.Due to the vicious cycle of oxidative stress,bacterial infection,excessive inflammatory response,and impaired angiogenesis,the healing process of diabetic wounds is disrupted,leading to the formation of chronic wounds.Although a variety of clinical methods have been investigated for the treatment of diabetic wounds,the results have not been satisfactory.Metals and their composites are expected to solve these problems.The study found that metal ions are involved in the synthesis and transformation of a variety of enzymes and proteins,thereby affecting a range of cellular activities.However,due to the sudden release and cytotoxicity of metal ions,it is necessary to modify them.At present,silver(Ag),copper(Cu),zinc(Zn),gold(Au)and other metals as nanoparticles and metal-organic skeleton,as well as their composites combined with biological materials(such as chitosan,sodium alginate,and antibiotics)have been widely used and studied in diabetic wounds.In vitro experiments showed that the metals and their composites had good biocompatibility and stability,and inhibited the growth and reproduction of bacterial strains commonly found in diabetic wounds,including gram-positive and gram-negative bacteria.They demonstrated excellent anti-inflammatory,antioxidant,antibacterial and angiogenic properties,and ultimately promoted the healing of diabetic wounds.In summary,metals and their composites not only play a role in various stages of diabetic wound healing,but also provide a stable physiological environment for the process of diabetic wound healing,which is a promising new strategy for the treatment of diabetic wound healing.

关 键 词：金属纳米颗粒 金属有机框架 生物材料 糖尿病创面愈合 

分 类 号：Q819[生物学—生物工程]