老年冠状动脉支架植入患者术后冠状动脉事件再发生情况及其与单核细胞/高密度脂蛋白胆固醇、中性粒细胞/淋巴细胞的关系  

Recurrence of postoperative coronary events in elderly patients with coronary stent implantation and its relationship with monocyte to high-density lipoprotein cholesterol ratio and neutrophil to lymphocyte ratio

作　　者：邵晨 赵志伟 牛利利 Shao Chen;Zhao Zhiwei;Niu Lili(Department of Cardiovascular Medicine,the Second People's Hospital of Lianyungang,Lianyungang 222000,Jiangsu,China)

机构地区：[1]连云港市第二人民医院心血管内科,江苏连云港222000

出　　处：《血管与腔内血管外科杂志》2024年第10期1259-1263,共5页Journal of Vascular and Endovascular Surgery

基　　金：连云港市老龄健康科研项目(L202209)。

摘　　要：目的探讨老年冠状动脉支架植入患者术后冠脉事件再发生情况及其与单核细胞/高密度脂蛋白胆固醇(MHR)、中性粒细胞/淋巴细胞(NLR)的关系。方法收集2020年6月至2023年3月于连云港市第二人民医院接受冠状动脉支架植入术治疗的120例老年患者的临床资料,按照术后1年冠状动脉事件再发生情况将其分为再发生组(n=32)和非再发生组(n=88)。比较两组患者术前MHR、NLR值,分析其与老年冠状动脉支架植入患者术后冠状动脉事件再发生的相关性,采用受试者工作特征曲线(ROC)分析MHR、NLR对术后冠状动脉事件再发生的预测价值。结果再发生组患者的MHR、NLR水平均高于非再发生组患者,差异均有统计学意义(P﹤0.05)。Spearman相关分析显示,MHR、NLR水平与老年冠状动脉支架植入术后冠状动脉事件再发生呈正相关(r=0.369、0.490,P﹤0.05)。ROC曲线显示,MHR、NLR联合预测老年冠状动脉支架植入术后冠状动脉事件再发生的曲线下面积(AUC)为0.918,灵敏度为90.62%,特异度为89.77%,联合预测的效能优于各指标单独预测(P﹤0.05)。结论老年冠状动脉支架植入患者术后冠状动脉事件再发生风险较高,与MHR、NLR水平密切相关,早期测定MHR、NLR水平可预测老年冠状动脉支架植入患者术后冠状动脉事件的再发生情况。Objective To investigate the recurrence of postoperative coronary events in elderly patients with coronary stent implantation(CSI)and its relationship with monocyte to high-density lipoprotein cholesterol ratio(MHR)and neutrophil to lymphocyte ratio(NLR).Method The clinical data of 120 elderly patients who received coronary stenting in the Second People's Hospital of Lianyungang from June 2020 to March 2023 were collected.According to the recurrence of coronary artery events one year after surgery,they were divided into recurrence group(n=32)and non-recurrence group(n=88).The preoperative MHR and NLR values of the two groups were compared,the correlation and the recurrence of coronary events after coronary stent implantation in elderly patients was analyzed.The predictive value of MHR and NLR on the recurrence of postoperative coronary events were analyzed by receiver operator characteristic(ROC).Result The levels of MHR and NLR in recurrence group were higher than those in non-recurrence group,with statistical significance(P<0.05).Spearman correlation analysis showed that the levels of MHR and NLR were positively correlated with the recurrence of coronary events after coronary stenting in elderly patients(r=0.369,0.490,P<0.05).ROC curve showed that the area under curve(AUC)of MHR and NLR in predicting the recurrence of coronary events after coronary stenting in elderly patients was 0.918,the sensitivity was 90.62%,and the specificity was 89.77%,the combined prediction efficiency was better than that of each index alone(P<0.05).Conclusion The risk of recurrence of coronary events is higher in elderly patients with coronary stent implantation,which is closely related to the levels of MHR and NLR.Early detection of MHR and NLR levels can predict the recurrence of coronary events in elderly patients with coronary stent implantation.

关 键 词：冠状动脉支架植入术 术后冠状动脉事件再发生 单核细胞/高密度脂蛋白胆固醇 中性粒细胞/淋巴细胞 相关性 预测价值 

分 类 号：R543[医药卫生—心血管疾病]