高血压与抗高血压药物对勃起功能障碍的影响及机制的研究进展  

Influence of hypertension and antihypertensive drugs on erectile dysfunction and the underlying mechanism:An update

作　　者：冯洪明 刘帅(综述) 傅强(审校) FENG Hong-ming;LIU Shuai;FU Qiang(Department of Urology,Shandong Provincial Hospital,Shandong First Medical University,Jinan,Shandong 250021,China)

机构地区：[1]山东第一医科大学附属省立医院泌尿外科,山东济南250021

出　　处：《中华男科学杂志》2024年第11期1036-1042,共7页National Journal of Andrology

摘　　要：高血压是最常见的慢性病,是心脑血管病最主要的危险因素,而且与勃起功能障碍(ED)的形成与发展密切相关。既有研究证实,由于存在共病机制,高血压是ED的风险因素之一,ED也可以被看作心血管疾病的“消息树”。在高血压期间,促血管收缩因子(醛固酮、去甲肾上腺素、ET-1)打破了血管收缩与舒张的平衡,并进一步影响血管与勃起功能。此外,研究证实多种抗高血压药影响勃起功能(正向或负向)。本文主要综合近年来该领域的研究成果,论述高血压和抗高血压药对勃起功能的影响,并对其具体机制进行探讨总结。Hypertension is a most common chronic disease and a most important risk factor for cardiovascular and cerebrovascular diseases,and is also closely related to the development and progression of erectile dysfunction(ED).Existing evidence shows that hypertension is a risk factor for ED due to comorbidities.ED can also be regarded as the"message tree"of cardiovascular diseases.During hypertension,pro-vasoconstrictor factors,such as aldosterone,norepinephrine,and ET-1,break the balance between vasoconstriction and vasodilation,and consequently affect vascular and erectile function.Furthermore,relevant studies have confirmed the influence of various antihypertensive drugs on erectile function,either positively or negatively.This review summarizes the findings in the relevant studies over the past five years,focusing on the effects of hypertension and antihypertensive drugs on erectile function and the specific underlying mechanisms.

关 键 词：勃起功能障碍 高血压 抗高血压药 共病机制 

分 类 号：R698.1[医药卫生—泌尿科学] R544.1[医药卫生—外科学]