个性化Gyroid结构髁突假体设计及对关节盘的有限元分析  

Design of customized Gyroid condylar prosthesis and finite element analysis of articular disc

作　　者：姜婷婷 刘丹瑜 姜至秀 季俣辰 曹怡琳 宿玉成 王心彧[1,2] Jiang Tingting;Liu Danyu;Jiang Zhixiu;Ji Yuchen;Cao Yilin;Su Yucheng;Wang Xinyu(Jiamusi University,Jiamusi 154003,Heilongjiang Province,China;Key Laboratory of Oral Biomaterials and Clinical Applications of Heilongjiang Province,Stomatology Engineering Experimental Center of Jiamusi University,Stomatology College of Jiamusi University,Jiamusi 154007,Heilongjiang Province,China;Dental Implant Center,Peking Union Medica College Hospital,Chinese Academy of Medical Sciences,Beijing 100032,China;Beijing Implant Training College(BITC),Beijing Citident Stomatology Hospital,Beijing 100032,China)

机构地区：[1]佳木斯大学,黑龙江省佳木斯市154003 [2]黑龙江省口腔生物材料与临床应用重点实验室,佳木斯大学口腔医学工程研究中心,佳木斯大学附属口腔医院,黑龙江省佳木斯市154007 [3]中国医学科学院北京协和医院口腔种植中心,北京市100032 [4]北京瑞城口腔医院,北京口腔种植培训中心,北京市100032

出　　处：《中国组织工程研究》2025年第28期6003-6011,共9页Chinese Journal of Tissue Engineering Research

基　　金：黑龙江省自然科学基金项目(LH2022H089),项目负责人:王心彧;黑龙江省卫生健康委科研课题项目(2020-314),项目负责人:王心彧。

摘　　要：背景:人工髁突假体置换作为治疗颞下颌关节疾病的手术方式之一,不仅要恢复形态和功能,还要保证长期稳定的应用。目的:设计个性化Gyroid结构髁突假体并进行有限元分析。方法:通过软件设计不同壁厚(250,350,450,550,650,750μm)的Gyroid结构试件,分别进行有限元模拟压缩实验,检测试件的弹性模量,筛选出与下颌骨松质骨弹性模量相匹配且孔径满足成骨条件的Gyroid结构壁厚区间,对此区间进行细分并利用3D打印技术制作Gyroid结构试件,进行万能试验机力学压缩实验,通过弹性模量与抗压强度筛选符合下颌骨力学性能、孔径更易成骨且强度较小的Gyroid结构壁厚,进行后续实验。设计下颌骨个性化Gyroid结构髁突假体三维模型,分别模拟模型在自然咬合状态下对刃颌位、牙尖交错位的有限元分析。结果与结论:①有限元分析结果显示,随着壁厚的增加,Gyroid结构试件的弹性模量升高,其中壁厚350,450,550,650,750μm Gyroid结构试件的弹性模量与下颌骨松质骨弹性模量相匹配,由于后续实验需细分组别且550,650,750μm壁厚组孔径(800-1000μm)在成骨范围内,故筛选出壁厚550,600,650,700,750μm Gyroid结构试件进行万能试验机力学压缩实验;②力学压缩实验结果显示,随着壁厚的增加,Gyroid结构试件的弹性模量与抗压强度升高,其中壁厚550,600,650μm Gyroid结构试件的弹性模量在下颌骨松质骨弹性模量范围内,最终选取壁厚650μm、孔径900μm进行下颌骨个性化Gyroid结构髁突假体三维模型构建;③下颌骨个性化Gyroid结构髁突假体三维模型有限元分析结果显示,对刃颌位关节盘应力主要集中在前中带下表面,牙尖交错位关节盘应力主要集中在下表面外侧,左右侧关节盘在对刃颌位、牙尖交错位的最大位移和等效应力相近,最大位移分别为0.031,0.030,0.028,0.018 mm,最大等效应力分别为2.87,2.30,2.73,1.71 MPa;④结果表明,壁�BACKGROUND:Condylar prosthesis replacement,as one of the surgical methods for the treatment of temporomandibular joint diseases,not only needs to restore the morphology and function,but also needs to ensure long-term stable application.OBJECTIVE:To design finite element analysis of a customized Gyroid condylar prosthesis.METHODS:Gyroid structure specimens with different wall thicknesses(250,350,450,550,650,and 750μm)were designed by software.Finite element simulation compression experiments were carried out to test the elastic modulus of the specimens.The Gyroid structure wall thickness range that matches the elastic modulus of mandibular cancellous bone and whose pore size meets the osteogenesis conditions was screened out.This range was subdivided and Gyroid structure specimens were made using 3D printing technology.Mechanical compression experiments were carried out on a universal testing machine.The Gyroid structure wall thickness that meets the mechanical properties of mandibular bone,has an easier osteogenesis and a smaller strength was screened out by elastic modulus and compressive strength,and subsequent experiments were carried out.A three-dimensional model of a customized Gyroid condylar prosthesis was designed,and the finite element analysis of the blade jaw position and cusp interdigitation position of the model under natural occlusion was simulated.RESULTS AND CONCLUSION:(1)Finite element analysis results showed that with the increase of wall thickness,the elastic modulus of Gyroid structure specimens increased.The elastic modulus of Gyroid structure specimens with wall thickness of 350,450,550,650,and 750μm matched the elastic modulus of mandibular cancellous bone.Since the subsequent experiments needed to be subdivided into groups and the pore size of the 550,650,and 750μm wall thickness group(pore size 800-1000μm)was within the osteogenesis range.Gyroid structure specimens with wall thickness of 550,600,650,700,and 750μm were selected for mechanical compression experiments on a universal tes

关 键 词：Gyroid结构 壁厚 髁突假体 有限元分析 关节盘 颞下颌关节 

分 类 号：R459.9[医药卫生—治疗学] R319[医药卫生—临床医学] R782.6