富血小板血浆与透明质酸治疗膝骨关节炎的系统评价再评价  

Platelet rich plasma versus hyaluronic acid in treatment of knee osteoarthritis:an overview of systematic reviews

作　　者：张云逸 柳松涛 谢韶东[2] 朱海丰 钱桂凤 霍明 周杰 邓子璇 Zhang Yunyi;Liu Songtao;Xie Shaodong;Zhu Haifeng;Qian Guifeng;Huo Ming;Zhou Jie;Deng Zixuan(Eighth Clinical Medical College,Guangzhou University of Chinese Medicine,Foshan 528000,Guangdong Province,China;Foshan Hospital of Traditional Chinese Medicine,Foshan 528000,Guangdong Province,China;Rehabilitation University(Preparatory),Qingdao 266000,Shandong Province,China)

机构地区：[1]广州中医药大学第八临床医学院,广东省佛山市528000 [2]佛山市中医院,广东省佛山市528000 [3]康复大学(筹),山东省青岛市266000

出　　处：《中国组织工程研究》2025年第28期6138-6145,共8页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金面上项目(82372585),项目负责人:霍明;广东省中医药管理局科研项目(20223017),项目负责人:周杰、谢韶东。

摘　　要：目的:系统评价/Meta分析的质量高低将影响临床决策依据的可靠性,目前国内外尚无对富血小板血浆与透明质酸治疗膝骨关节炎的系统评价/Meta分析进行文献质量评价的研究。该文对富血小板血浆与透明质酸治疗膝骨关节炎的系统评价/Meta分析进行方法学质量、报告质量和证据质量综合评价。方法:应用计算机检索中国知网、万方数据库、维普中文期刊数据库、中国生物医学文献服务系统、PubMed、Embase和The Cochrane Library等数据库,从建库至2024-01-24所有富血小板血浆与透明质酸治疗膝骨关节炎的系统评价/Meta分析,由2位评价员独立进行文献筛选和数据提取,并运用AMSTAR 2、PRISMA 2020、GRADE系统分别对纳入的系统评价/Meta分析进行方法学质量、报告质量和证据质量的评估与总结。结果:共纳入18篇合格的系统评价/Meta分析,结果显示富血小板血浆治疗膝骨关节炎的有效性和安全性可能优于透明质酸。18篇文献的方法学质量均为极低质量,其中4篇报告质量较差,存在相对严重的信息缺陷;14篇报告质量中等,有一定的信息缺陷;16篇系统评价/Meta分析的275个结局指标中,有9个中质量证据,90个低质量证据,176个极低质量证据,没有高质量证据。结论:现阶段富血小板血浆与透明质酸治疗膝骨关节炎的系统评价/Meta分析文献质量较低,今后的系统评价作者需在计划书注册、研究类型解释、检索策略、排除清单、研究场所和资金来源、偏倚风险分析、发表偏倚评估、公开信息获取等方面严格按照AMSTAR 2和PRISMA 2020等质量评估工具条目进行规范,对系统评价/Meta分析的合并结果进行证据质量评估,为临床提供更可靠、严谨的循证依据。OBJECTIVE:The quality of systematic reviews/meta-analyses directly affects the reliability of clinical decision-making basis.Currently,there is no literature quality research on the systematic reviews/meta-analyses of platelet rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis both domestically and internationally.This article will comprehensively evaluate the methodological quality,reporting quality,and evidence quality of the systematic reviews/meta-analyses of platelet rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis.METHODS:Computer searches were conducted on CNKI,WanFang Data,VIP,CBM,PubMed,Embase,and The Cochrane Library.From the establishment of the database until January 24,2024,all systematic reviews/meta-analyses treated with platelet rich plasma versus hyaluronic acid for knee osteoarthritis were collected.Two evaluators independently conducted literature screening and data extraction,and used the AMSTAR 2,PRISMA 2020,and GRADE systems to evaluate and summarize the methodological,reporting,and evidence quality of the included systematic reviews/meta-analyses.RESULTS:A total of 18 qualified systematic reviews/meta-analyses were included,and the results showed that the efficacy and safety of platelet rich plasma might be better than that of hyaluronic acid.The methodological quality of all 18 studies was extremely low;4 reports had poor quality and relatively serious information defects,while 14 reports had moderate quality and some information defects.Among the 275 outcome measures of 16 systematic reviews/metaanalyses,there were 9 medium quality evidence,90 low-quality evidence,and 176 extremely low-quality evidence,with no high-quality evidence.CONCLUSION:At present,the quality of systematic reviews/meta-analyses literature on the treatment of knee osteoarthritis with platelet rich plasma versus hyaluronic acid is relatively low.In the future,the authors of the systematic reviews need to strictly follow the entries of quality evaluation tools such as A

关 键 词：富血小板血浆 透明质酸 膝骨关节炎 系统评价再评价 AMSTAR 2 PRISMA 2020 GRADE系统 

分 类 号：R459.9[医药卫生—治疗学] R319[医药卫生—临床医学] R684.3