鲍曼不动杆菌外膜蛋白33-36的研究进展  

RESEARCH PROGRESS OF ACINETOBACTER BAUMANNII OUTER MENMBR-ANE PROTEIN OMP33-36

作　　者：侯卫花 朝鲁门其其格 王俊瑞[2] 刘慧[1] 李如 喇嘉琪 HOU Weihua;Chaolumenqiqige;WANG Junrui;LIU Hui;LI Ru;LA Jiaqi(First Clinical Medical College,Inner Mongolia Medical University,Hohhot 010059,China;Children's Intensive Care Unit,The Affliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China)

机构地区：[1]内蒙古医科大学第一临床医学院,内蒙古呼和浩特010059 [2]内蒙古医科大学附属医院儿童重症监护病房,内蒙古呼和浩特010050

出　　处：《内蒙古医科大学学报》2024年第4期418-421,438,共5页Journal of Inner Mongolia Medical University

基　　金：内蒙古自治区自然科学基金项目(2020MS08113);内蒙古自治区蒙医药协同创新中心科学研究项目(MYYXTYB202109);内蒙古医科大学面上项目(YKD2022MS008)。

摘　　要：鲍曼不动杆菌(acinetobacter baumannii,AB)是院内感染常见的不动杆菌之一,尤其在重症监护病房,常导致患者临床结局恶化,增加患者经济负担。目前对于AB的研究主要集中于致病机制、耐药性等方面,其中外膜蛋白33-36作为重要的致病因子,一直是研究热点。本文将从AB外膜蛋白33-36的致病机制、耐药性方面总结外膜蛋白33-36的研究进展。Acinetobacter baumannii(AB)is a Gram-negative coccobacteria,which is one of the common acinetobacter in nosocomial infections.Especially in intensive care units,it often leads to deterioration of clinical outcomes and increases the economic burden of patients.At present,the research on AB mainly focuses on the pathogenic mechanism,drug resistance and so on.Outer membrane protein 33-36,as an important pathogenic factor,has always been a research hotspot.This article will summarize the research progress of outer membrane protein 33-36 from the aspects of pathogenic mechanism and drug resistance of AB outer membrane protein 33-36.

关 键 词：鲍曼不动杆菌 Omp33-36 致病机制 耐药性 抗原性与亚单位疫苗 

分 类 号：R274.9[医药卫生—中西医结合]