铁死亡在口腔鳞状细胞癌机制中的研究进展  

PROGRESS IN STUDYING FERROPTOSIS IN THE MECHANISM OF ORAL SQUAMOUS CELL CARCINOMA

作　　者：王立华 周兴安 七十 WANG Lihua;ZHOU Xingan;QI Shi(College of Stomatology,Inner Mongolia Medical University,Hohhot 010059,China;Department of Stomatology,The Afiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China;Inner Mongolia Stomatological Hospital(Hohhot Stomatological Hospital),Hohhot 010020,China)

机构地区：[1]内蒙古医科大学口腔医学院,内蒙古呼和浩特010059 [2]内蒙古医科大学附属医院口腔科,内蒙古呼和浩特010050 [3]呼和浩特市口腔医院(内蒙古自治区口腔医院),为蒙古呼和浩特010020

出　　处：《内蒙古医科大学学报》2024年第4期422-425,434,共5页Journal of Inner Mongolia Medical University

基　　金：内蒙古自治区自然科学基金项目(2023MS08045);呼和浩特市科技局科技计划项目(应用技术研究与开发)(2023-社-26)。

摘　　要：口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)是口腔颌面部常见的恶性肿瘤之一,特点是侵袭性强、局部淋巴结转移和预后不良。铁死亡的主要机制是铁离子介导的细胞内脂质过氧化物的积累,从而导致细胞破裂和细胞死亡。深入探究铁死亡的生物学途径及相关通路,以及与免疫、代谢和基因等因素的调控,不仅有助于我们更好地理解其在OSCC中的调控作用,而且能够为OSCC的诊断和治疗提供新的思路和方法。Oral squamous cell carcinoma(OSCC)is one of the common malignant tumors in the oral and maxillofacial region,characterized by aggressive,local lymph node metastasis and poor prognosis.Iron death,and the main mechanism is the iron-ion-mediated accumulation of intracellular lipid peroxides,which leads to cell breakdown and cell death.In-depth exploration of the biological pathways and related pathways of iron death,as well as the regulation of immune,metabolic and genetic factors,will not only help us to better understand its regulatory role in OSCC,but also can provide new ideas and methods for the diagnosis and treatment of OSCC.

关 键 词：OSCC 铁死亡 机制 

分 类 号：R274.9[医药卫生—中西医结合]