自膨胀止血材料的研究进展  

Research progress on self-expanding hemostatic materials

作　　者：符芬 乔晓燕[1] 王钰涵 赵帆 王璐[1,2,3] 曾泳春[1,3] 王富军[1,2,3] Fu Fen;Qiao Xiaoyan;Wang Yuhan;Zhao Fan;Wang Lu;Zeng Yongchun;Wang Fujun(College of Textiles,Donghua University,Shanghai 201620,China;Key Laboratory of Textile Science and Technology,Ministry of Education,Donghua University,Shanghai 201620,China;Shanghai Frontiers Science Center of Advanced Textiles,Donghua University,Shanghai 201620,China)

机构地区：[1]东华大学纺织学院,上海201620 [2]东华大学纺织面料技术教育部重点实验室,上海201620 [3]东华大学上海市现代纺织前沿科学研究基地,上海201620

出　　处：《产业用纺织品》2024年第11期1-8,共8页Technical Textiles

基　　金：上海市东方英才计划(青年项目)(ZX202404290062);浙江省科技支撑计划(ZX202402270018)。

摘　　要：自膨胀止血材料因优异的伤口填充性和血液浓缩能力,在止血应用中表现突出,成为止血材料近年研究的热点。通过分析自膨胀止血材料的止血机理,阐述多孔结构与材料吸液自膨胀特性的联系及其对止血功效的影响;对比总结国内外此类产品的发展概况;着重介绍冷冻干燥法、纺丝直接成型法、气体发泡法、3D打印法等自膨胀止血材料构建方法的研究进展,简要分析各种方法的优劣,指出自膨胀止血材料未来研究重点和需应对的挑战。Self-expanding hemostatic materials have emerged as a hot spot in hemostatic materials research due to their exceptional wound filling properties and blood-concentrating capabilities,making significant strides in hemostatic applications.By analyzing the hemostatic mechanism of self-expanding materials,the relationship between their porous structures and the ability to absorb liquids and expand imbibition self-expansion characteristic,as well as the impact of these characteristics on hemostasis were expounded.A comparative analysis was provided on the development of such products both domestically and internationally.The advancements in fabrication strategies for self-expanding materials,including methods such as freeze-drying,direct melt extrusion,gas foaming and 3D printing,were discussed.Additionally,a brief analysis of the strengths and weaknesses of various techniques was presented,as well as future research focuses and challenges that needed to be addressed for self-expanding hemostatic materials were pointed out.

关 键 词：止血 自膨胀 生物材料 冷冻干燥 纺丝直接成型 气体发泡 3D打印 

分 类 号：R319[医药卫生—基础医学]