中药浸膏片干法制粒工艺研究  

Study on the Dry Granulation Technology of Traditional Chinese Medicine Extract Tablets

作　　者：何坦 叶彬 杨超 赖惠玲 HE Tan;YE Bin;YANG Chao;LAI Huiling(Guangzhou Baiyunshan Zhongyi Pharmaceutical Co.,Ltd.,Guangzhou 510700,China)

机构地区：[1]广州白云山中一药业有限公司,广东广州510700

出　　处：《山东化工》2024年第21期41-43,共3页Shandong Chemical Industry

摘　　要：目的:本研究选取中药浸膏粉末进行干法制粒工艺优选,探索解决中药浸膏片干法制粒工艺成型问题。方法:通过沸腾制粒和干法制粒的工艺对比和筛选,再经总混、压片,考察浸膏片采用干法制粒进行制剂成型的工艺质量稳定性和可行性。结果:中药全浸膏粉通过干法制粒可以进行压片生产,片芯质量符合标准要求,片剂成型工艺稳定可行。结论:干法制粒可以有效解决浸膏片黏性大、难成型问题,工艺处方科学实用,稳定性良好。优选后的浸膏片干法制粒工艺经中试放大试验,证明工艺稳定可行,可为全浸膏片工业生产提供参考。Objective:This study selected traditional Chinese medicine extract powder for optimal dry granulation process,and explored the solution to the problem of dry granulation process for traditional Chinese medicine extract tablets.Method:By comparing and screening the processes of boiling granulation and dry granulation,and then conducting total mixing and tablet pressing,the stability and feasibility of the process quality of using dry granulation to form the extract tablets were investigated.Result:The traditional Chinese medicine extract powder can be produced by dry granulation,and the core quality meets the standard requirements.The tablet forming process is stable and feasible.Conclusion:The dry granulation method can effectively solve the problems of high viscosity and difficulty in forming the extract tablets.The process prescription is scientific and practical,and the stability is good.The optimized dry granulation process for extract tablets has been tested in a pilot scale,which proves that the process is stable and feasible,and can provide reference for the industrial production of full extract tablets.

关 键 词：全浸膏片 干法制粒 片剂成型 工艺参数 

分 类 号：TQ461[化学工程—制药化工]