血尿酸水平与无呼吸系统疾病2型糖尿病患者肺功能关系研究  

Relationship between serum uric acid level and pulmonary functionin type 2 diabetic patients without respiratory disease

作　　者：程阳 王奕 赵晓宇 申格格 李梦颖 王铖 王鑫 丁文华 许晓双 周洁 李晓苗 CHENG Yang;WANG Yi;ZHAO Xiaoyu;SHEN Gege;LI Mengying;WANG Cheng;WANG Xin;DING Wenhua;XU Xiaoshuang;ZHOU Jie;LI Xiaomiao(Department of Endocrinology,the First Affiliated Hospital of Air Force Medical University,Xi’an 710032,China)

机构地区：[1]空军军医大学第一附属医院内分泌科,陕西西安710032

出　　处：《陕西医学杂志》2024年第12期1629-1634,共6页Shaanxi Medical Journal

基　　金：国家自然科学基金资助项目(82070839);空军军医大学第一附属医院学科助推项目(XJZT24QN29)。

摘　　要：目的:分析血尿酸(UA)水平与无呼吸系统疾病2型糖尿病(T2DM)患者肺功能的关系。方法:选取无呼吸系统疾病的T2DM患者464例,根据是否出现通气和弥散功能障碍分为通气功能障碍组(119例)、通气功能正常组(345例)以及弥散功能障碍组(150例)、弥散功能正常组(314例),分别比较两组患者临床资料。采用Spearman秩相关和Logistic回归分析UA与无呼吸系统疾病T2DM患者肺功能的关系。结果:通气功能障碍组与通气功能正常组患者年龄、性别、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、UA比较差异有统计学意义,且通气功能障碍组UA水平高于通气功能正常组(均P<0.05)。弥散功能障碍组与弥散功能正常组患者年龄、性别、体重指数(BMI)、γ-谷氨酰基转移酶(γ-GT)、谷丙转氨酶(ALT)、直接胆红素(D-BIL)、间接胆红素(I-BIL)、TC、UA、肾小球滤过率(eGFR)比较差异有统计学意义,且弥散功能障碍组UA水平高于弥散功能正常组(均P<0.05)。Spearman秩相关分析显示,UA水平与用力肺活量占预计值百分比(FVC%pred)、第1秒末用力呼气容积占预计值百分比(FEV1%pred)、一氧化碳弥散量占预计值百分比(DLCO%pred)呈负相关(r_(s)=-0.204、-0.194、-0.109,均P<0.05)。Logistic回归分析显示,调整混杂因素后,合并高尿酸血症(HUA)与患者肺通气、弥散功能降低独立相关(均P<0.05)。结论:对于无呼吸系统疾病的T2DM患者,UA水平与FVC%pred、FEV1%pred、DLCO%pred呈负相关,合并HUA是T2DM患者肺功能降低的独立影响因素。Objective:To investigate the relationship between serum uric acid(UA)level and pulmonary function in type 2 diabetic(T2DM)patients without respiratory disease.Methods:A total of 464 T2DM patients without respiratory diseases were divided into ventilation dysfunction group(119 cases),normal ventilation function group(345 cases),and diffusion dysfunction group(150 cases),normal diffusion function group(314 cases)according to the presence or absence of ventilation and diffusion dysfunction.The clinical data of the two groups were compared.Spearman rank correlation and Logistic regression were used to analyze the relationship between UA and pulmonary function in T2DM patients without respiratory diseases.Results:There were significant differences in age,gender,TC,TG,HDL-C and UA between ventilation dysfunction group and normal ventilation function group,and the UA level in the ventilation dysfunction group was higher than that in the normal ventilation function group(all P<0.05).There were significant differences in age,gender,BMI,γ-GT,ALT,D-BIL,I-BIL,TC,UA and eGFR between diffusion dysfunction group and normal diffusion function group,and the UA level in the diffusion dysfunction group was higher than that in the normal diffusion function group(all P<0.05).Spearman rank correlation analysis showed that the UA level was negatively correlated with FVC%pred,FEV1%pred and DLCO%pred(r s=-0.204,-0.194,-0.109,all P<0.05).Logistic regression analysis showed that after adjusting for confounding factor_(s),hyperuricemia(HUA)was independently associated with decreased pulmonary ventilation and diffusion function(all P<0.05).Conclusion:In T2DM patients without respiratory diseases,UA level is negatively correlated with FVC%pred,FEV1%pred and DLCO%pred.HUA is an independent risk factor for reduced lung function in T2DM patients.

关 键 词：2型糖尿病 肺弥散功能 肺通气功能 尿酸 高尿酸血症 关系 

分 类 号：R587.1[医药卫生—内分泌]