RNA结合蛋白QKI在动脉粥样硬化发病机制中的研究进展  

Research Progress of RNA-Binding Protein QKI in Pathogenesis of Atherosclerosis

作　　者：叶孜 王云沛 李晓洁 廖苑竹 楼迪栋 周谊霞 YE Zi;WANG Yunpei;LI Xiaojie;LIAO Yuanzhu;LOU Didong;ZHOU Yixia(Basic Medicine School,Guizhou University of Traditional Chinese Medicine,Guiyang 550025,China;Nursing School,Guizhou University of Traditional Chinese Medicine,Guiyang 550025,China)

机构地区：[1]贵州中医药大学基础医学院,贵阳550025 [2]贵州中医药大学护理学院,贵阳550025

出　　处：《医学综述》2024年第24期2950-2955,共6页Medical Recapitulate

基　　金：国家自然科学基金(82160099,81860089);贵州省高层次创新型百层次人才(黔科合平台人才-GCC[2023]085)。

摘　　要：动脉粥样硬化(As)是一种由多种致病因素作用于血管壁所致的慢性炎症性疾病。目前As的发病机制尚未完全阐明,有效防治As、抑制As的发生发展已成为近年心血管领域研究的热点。QKI是RNA结合蛋白中高度保守的信号转导和RNA活化蛋白家族成员,参与脂质代谢、炎症反应、血管重构等生理活动,与As的发病机制密切相关。因此,进一步阐明QKI在As发生中的作用及机制,可以为As的治疗提供新思路。Atherosclerosis(As)is a chronic inflammatory disease caused by a variety of pathogenic factors acting on the blood vessel wall.So far,the pathogenesis of As has not been fully elucidated.Effective prevention and treatment of As and inhibition of the occurrence and development of As has become a hot topic in the field of cardiovascular research in recent years.Quaking(QKI)is a member of a highly conserved signal transduction and activator of RNA family of RNA-binding protein,which participates in lipid metabolism,inflammatory response,vascular remodeling and other physiological activities,and is closely related to the pathogenesis of As.Therefore,further elucidating the role and mechanism of QKI in the occurrence of As can provide new ideas for the treatment of As.

关 键 词：动脉粥样硬化 QKI 脂质代谢 炎症反应 血管重构 

分 类 号：R543.5[医药卫生—心血管疾病]