脓毒症相关急性肾损伤发病机制及其诊断和预后标志物的研究进展  

Research Progress in Pathogenesis and Diagnostic and Prognostic Markers of Sepsis-associated Acute Kidney Injury

作　　者：王佩雯 赵霄君 许亚楠 王倩梅 李俊杰 WANG Peiwen;ZHAO Xiaojun;XU Yanan;WANG Qianmei;LI Junjie(Graduate Department,Xi′an Medical University,Xi′an 710068,China;Department of Emergency,Xijing Hospital of Air Force Military Medical University,Xi′an 710032,China)

机构地区：[1]西安医学院研究生部,西安710068 [2]空军军医大学西京医院急诊科,西安710032

出　　处：《医学综述》2024年第24期2956-2960,2968,共6页Medical Recapitulate

基　　金：西京医院医务人员培养助推项目(XJZT24CY22);空军军医大学临床研究项目(2023LC2335)。

摘　　要：脓毒症相关急性肾损伤(SA-AKI)是一类特殊的危重症急性肾损伤(AKI),其病死率高,预后差,给社会和家庭造成沉重负担。SA-AKI的病理生理机制复杂,主要涉及炎症及免疫反应、血流动力学不稳定、微循环障碍、线粒体功能障碍等。目前,SA-AKI的早期诊断主要依赖尿量和血清肌酐值,但两者具有滞后性,这也导致临床上无法早期识别AKI和及时治疗。因此,探索SA-AKI的病理生理机制、寻找早期敏感及与预后相关的新型生物标志物极为重要。Sepsis-associated acute kidney injury(SA-AKI)is a special category of critical acute kidney injury(AKI)with high mortality and poor prognosis,which has caused a serious burden on the society and family.The pathophysiological mechanism of SA-AKI is complex,mainly involving inflammation and immune response,hemodynamics instability,microcirculation disorders,mitochondrial dysfunction and so on.At present,the early diagnosis of SA-AKI depends on urine volume and serum creatinine value,both of which have a lag,resulting in the failure of early clinical recognition of AKI and timely treatment.Therefore,it is extremely important to explore the pathophysiological mechanism of SA-AKI and search for new biomarkers that are sensitive in the early stages and related to prognosis.

关 键 词：脓毒症 急性肾损伤 器官功能障碍 病理机制 生物标志物 炎症 

分 类 号：R692[医药卫生—泌尿科学]