剪切稀化型生物墨水在3D生物打印组织气管中的研究进展  

Research progress of shear-thinning bioink in 3D bioprinting tissue trachea

作　　者：孙艺琪 徐翔宇 孙飞 单一波 沈志明 史宏灿 SUN Yiqi;XU Xiangyu;SUN Fei;SHAN Yibo;SHEN Zhiming;SHI Hongcan(Clinical Medical College,Yangzhou University,Yangzhou,225009,Jiangshu,P.R.China;Institute of Translational Medicine,Medical College,Yangzhou University,Yangzhou,225009,Jiangshu,P.R.China;Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Geriatric Diseases,Yangzhou University,Yangzhou,225009,Jiangshu,P.R.China)

机构地区：[1]扬州大学临床医学院,江苏扬州225009 [2]扬州大学医学院(转化医学研究院),江苏扬州225009 [3]江苏省中西医结合老年病防治重点实验室,江苏扬州225009

出　　处：《中国胸心血管外科临床杂志》2024年第12期1859-1864,共6页Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

基　　金：国家自然科学基金(82070020)。

摘　　要：剪切稀化是生物墨水的理想特性,因为其可减少堵塞的机会。对于基于挤出的生物打印,生物墨水在通过生物打印机时会经历剪切力。剪切速率会随着挤出速率的增加而增加,剪切稀化型生物墨水的表观粘度会减小,这使得其更不容易堵塞,从而实现3D打印组织的结构保真度。组织气管中复杂功能结构的制造需要生物墨水的精确逐层放置和凝固,剪切稀化型生物墨水或能满足此要求。本综述围绕剪切稀化型生物墨水的机械性能重要性、分类和制备方法,同时列出其目前在3D打印组织气管的应用现状,讨论该生物材料在组织气管中的更多可能性与前景。Shear thinning is an ideal feature of bioink because it can reduce the chance of blocking.For extrusion based biological printing,bioink will experience shear force when passing through the biological printer.The shear rate will increase with the increase of extrusion rate,and the apparent viscosity of shear-thinning bioink will decrease,which makes it easier to block,thus achieving the structural fidelity of 3D printing tissue.The manufacturing of complex functional structures in tissue trachea requires the precise placement and coagulation of bioink layer by layer,and the shear-thinning bioink may well meet this requirement.This review focuses on the importance of mechanical properties,classification and preparation methods of shear-thinning bioink,and lists its current application status in 3D printing tissue trachea to discuss the more possibilities and prospects of this biological material in tissue trachea.

关 键 词：剪切稀化 生物墨水 气管移植物 组织工程 3D打印 

分 类 号：TP391.73[自动化与计算机技术—计算机应用技术] R318.08[自动化与计算机技术—计算机科学与技术]