乙酰唑胺在急性失代偿性心力衰竭中的应用研究进展  

Research progress on the application of acetazolamide in acute decompensated heart failure

作　　者：吕梁 魏薇[1] LU Liang;WEI Wei(Department of Emergency Medicine,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,P.R.China)

机构地区：[1]四川大学华西医院急诊科,成都610041

出　　处：《华西医学》2024年第11期1787-1791,共5页West China Medical Journal

摘　　要：近年来,乙酰唑胺对治疗急性失代偿性心力衰竭(acute decompensated heart failure, ADHF)液体超负荷的潜在益处已引起研究者的关注。该文对乙酰唑胺的药理机制、在心力衰竭治疗中如何改善患者症状和临床预后以及临床应用的研究进展进行综述,旨在为临床医师调整和选择ADHF利尿剂综合应用方案提供理论和研究依据,并为进一步研发针对ADHF患者利尿剂抵抗的新药物提供新的思路和方向。In recent years,the potential benefits of acetazolamide in managing fluid overload in acute decompensated heart failure(ADHF)have attracted the attention of researchers.This article reviews the pharmacological mechanism of acetazolamide,how it improves patient symptoms and clinical prognosis in the treatment of heart failure,and the research progress in clinical application.The aim is to provide theoretical and research basis for clinicians to adjust and choose the comprehensive application plan of diuretics for ADHF,and to provide new ideas and directions for further research and development of new drugs targeting diuretic resistance in ADHF patients.

关 键 词：乙酰唑胺 急性失代偿性心力衰竭 利尿剂 利尿剂抵抗 代谢性碱中毒 

分 类 号：R541.6[医药卫生—心血管疾病]