针刺结合蜂胶降脂方治疗高脂血症痰瘀互结证患者的随机对照临床研究  

A Randomized Controlled Clinical Study on Acupuncture Combined with Propolis Lipid-Lowering Formula for Treating Hyperlipidemia with Phlegm and Blood Stasis Syndrome

作　　者：林海鸣 林怡 李心怡 陈焯贤 黄亮晴 谢晓明 贺珂 田贵华[1] LIN Haiming;LIN Yi;LI Xinyi;CHEN Zhuoxian;HUANG Liangqing;XIE Xiaoming;HE Ke;TIAN Guihua(Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China)

机构地区：[1]北京中医药大学东直门医院,北京100700

出　　处：《中医药学报》2024年第12期67-73,共7页Acta Chinese Medicine and Pharmacology

基　　金：北京市科学技术委员会公益应用类项目(Z181100009818022);中共中央组织部国家高层次青年人才计划项目;国家中医药管理局青年岐黄学者支持项目。

摘　　要：目的:探究中医针药结合疗法对高脂血症痰瘀互结证患者的疗效影响。方法:通过随机数字表法将2022年4月—2024年1月在北京中医药大学东直门医院招募到的95例高脂血症痰瘀互结证患者,随机分为针药结合组、针刺组、中药组、安慰剂组、假针刺组,每组19例。研究过程中,共计18例患者因各种原因剔除、中止或脱落,最终完成试验针药结合组16例,针刺组16例,中药组15例,安慰剂组15例,假针刺组15例。针药结合组给予针刺和冲服蜂胶降脂方颗粒剂治疗,针刺组给予针刺治疗,中药组给予冲服蜂胶降脂方颗粒剂治疗,安慰剂组给予冲服安慰颗粒剂干预,假针刺组给予假针针刺干预,疗程均为4周,比较患者干预前后BMI、中医证候评分、血脂四项水平的变化情况。结果:治疗4周后,针药结合组、针刺组、中药组BMI、中医证候评分均显著下降(P<0.05),且针刺组优于假针刺组(P<0.05),中药组优于安慰剂组(P<0.05),针药结合组优于针刺组和中药组(P<0.05)。针药结合组、针刺组TC均显著降低(P<0.05),且针刺组优于假针刺组(P<0.05)。针药结合组、中药组TG均显著降低(P<0.05),且中药组优于安慰剂组(P<0.05),针药结合组优于针刺组(P<0.05)。针药结合组HDL-C显著升高(P<0.05)。针药结合组LDL-C显著降低(P<0.05),且针刺组优于假针刺组(P<0.05),针药结合组优于中药组(P<0.05)。结论:针药结合治疗、针刺治疗、中药治疗均可不同程度地改善高脂血症痰瘀互结证患者的BMI、中医证候评分、血脂四项含量水平,且无不良反应。针药结合治疗优于单独的针刺治疗或中药治疗。Objective:To explore the efficacy of acupuncture combined with herbal medicine therapy in patients with hyperlipidemia and phlegm-blood stasis syndrome.Methods:Ninety-five patients with hyperlipidemia and phlegm-blood stasis syndrome,recruited at Dongzhimen Hospital of Beijing University of Chinese Medicine from April 2022 to January 2024,were randomly assigned into five groups:the combination therapy group,the acupuncture group,the herbal medicine group,the placebo group,and the sham acupuncture group,with 19 patients in each group.During the study,18 patients were excluded,discontinued,or dropped out for various reasons,leaving 16 patients in the combination therapy group,16 in the acupuncture group,15 in the herbal medicine group,15 in the placebo group,and 15 in the sham acupuncture group to complete the study.The combination therapy group received acupuncture and oral propolis lipid-lowering granules,the acupuncture group received acupuncture treatment,the herbal medicine group received oral propolis lipid-lowering granules,the placebo group received oral placebo granules,and the sham acupuncture group received sham acupuncture intervention.The treatment period for all groups was 4 weeks.Changes in BMI,TCM syndrome scores,and four lipid parameters before and after intervention were compared.Results:After 4 weeks of treatment,BMI and TCM syndrome scores significantly decreased in the combination therapy group,the acupuncture group,and the herbal medicine group(P<0.05).The acupuncture group showed better results than the sham acupuncture group(P<0.05),and the herbal medicine group showed better results than the placebo group(P<0.05).The combination therapy group had superior results compared to the acupuncture and herbal medicine groups(P<0.05).Total cholesterol(TC)significantly decreased in the combination therapy and acupuncture groups(P<0.05),with the acupuncture group outperforming the sham acupuncture group(P<0.05).Triglycerides(TG)significantly decreased in the combination therapy and herbal medicine gro

关 键 词：高脂血症 针刺疗法 中药疗法 针药结合疗法 

分 类 号：R245.31[医药卫生—针灸推拿学]