黄龙舒喘汤合三子养亲汤加味联合常规治疗对风痰恋肺证支气管哮喘患者的临床研究  

Effect of Huanglong Shuchuan Decoction Combined with Sanzi Yangqin Decoction in Patients with Bronchial Asthma and Wind-Phlegm Retaining in the Lung Syndrome

作　　者：鞠秋燕 章洁 周翔 JU Qiuyan;ZHANG Jie;ZHOU Xiang(Department of Respiratory and Critical Care Medicine,Rugao City Traditional Chinese Medicine Hospital,Nantong 226500,China)

机构地区：[1]如皋市中医院呼吸与危重症医学科,江苏南通226500

出　　处：《中医药学报》2024年第12期114-118,共5页Acta Chinese Medicine and Pharmacology

基　　金：江苏省社会发展面上项目(BE2020634)。

摘　　要：目的:探究黄龙舒喘汤合三子养亲汤加味联合常规治疗改善风痰哮患者的肺功能和免疫功能的效果。方法:选取2019年3月—2022年2月在如皋市中医院呼吸与危重症医学科治疗的122例风痰恋肺证支气管哮喘患者作为研究对象,根据随机数表法分为对照组和观察组,每组61例。对照组仅接受常规治疗,观察组在对照组基础上加用黄龙舒喘汤合三子养亲汤加味治疗。对比两组患者治疗前后的中医证候积分、哮喘控制测试(ACT)积分、肺功能指标[第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、1秒率(FEV1/FVC)、呼气流量峰值(PEF)]、气道炎症指标[嗜酸性粒细胞(EOS)、白细胞介素-4(IL-4)、白细胞介素-5(IL-5)、肿瘤坏死因子α(TNF-α)]及免疫功能指标(CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+))的差异。结果:治疗前,两组患者观察指标均无显著性差异(P>0.05)。治疗后,观察组的中医证候积分显著降低,哮喘控制测试(ACT)积分显著升高,且与对照组比较差异具有统计学意义(P<0.05)。观察组的肺功能指标FEV1、FEV1/FVC和PEF显著增高于对照组,差异有统计学意义(P<0.05)。气道炎症指标中,观察组EOS、IL-4、IL-5和TNF-α水平显著低于对照组,差异有统计学意义(P<0.05)。免疫功能指标方面,观察组的CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)显著高于对照组,差异具有统计学意义(P<0.05)。结论:黄龙舒喘汤合三子养亲汤加味联合常规治疗能够显著优化风痰哮患者的肺功能和免疫功能,为风痰恋肺证支气管哮喘患者的综合治疗提供了一种新的有效策略。Objective:To investigate the effect of Huanglong Shuchuan Decoction combined with Sanzi Yangqin Decoction on improving lung function and immune function in patients with bronchial asthma and wind-phlegm retaining in the lung syndrome.Methods:A total of 122 patients with bronchial asthma and wind-phlegm retaining in the lung syndrome,treated at Department of Respiratory and Critical Care Medicine,Rugao City Traditional Chinese Medicine Hospital from March 2019 to February 2022,were selected as research subjects.They were randomly divided into a control group and an observation group,with 61 patients in each group.The control group received only conventional treatment,while the observation group received Huanglong Shuchuan Decoction combined with Sanzi Yangqin Decoction in addition to conventional treatment.The differences in Traditional Chinese Medicine(TCM)syndrome scores,Asthma Control Test(ACT)scores,lung function indicators[Forced Expiratory Volume in 1 second(FEV1),Forced Vital Capacity(FVC),FEV1/FVC ratio,Peak Expiratory Flow(PEF)],airway inflammation indicators[Eosinophils(EOS),Interleukin-4(IL-4),Interleukin-5(IL-5),Tumor Necrosis Factor-α(TNF-α)],and immune function indicators(CD3^(+),CD4^(+),CD4^(+)/CD8^(+))before and after treatment were compared between the two groups.Results:Before treatment,there were no significant differences between the two groups in the observed indicators(P>0.05).After treatment,the TCM syndrome scores in the observation group were significantly reduced,and ACT scores were significantly increased,with statistical significance compared to the control group(P<0.05).Lung function indicators FEV1,FEV1/FVC ratio,and PEF in the observation group were significantly higher than those in the control group,with statistical significance(P<0.05).Airway inflammation indicators,including EOS,IL-4,IL-5,and TNF-αlevels,were significantly lower in the observation group compared to the control group,with statistical significance(P<0.05).In terms of immune function indicators,the levels of CD3^

关 键 词：黄龙舒喘汤合三子养亲汤加味 风痰恋肺证 支气管哮喘 肺功能 免疫功能 

分 类 号：R256.12[医药卫生—中医内科学]