α-卤代萘咪酮类衍生物的高效合成  

Efficient Synthesis of α-Halogenated Nafimidone Derivatives

作　　者：沈佳斌 陈丹丹 杜芸芸 盛荟茹 葛凯 SHEN Jiabin;CHEN Dandan;DU Yunyun;SHENG Huiru;GE Kai(School of Chemical Engineering and Technology,Tianjin University,Tianjin 300350,China;School of Biological and Environmental Engineering,Zhejiang Shuren University,Hangzhou 310023,China)

机构地区：[1]天津大学化工学院,天津300350 [2]浙江树人大学生物与环境工程学院,浙江杭州310023

出　　处：《湖州师范学院学报》2024年第10期21-26,57,共7页Journal of Huzhou University

基　　金：国家自然科学基金青年科学基金项目(22408344)。

摘　　要：以碘化亚铜为催化剂、廉价卤化钾为卤源,高效制备α-卤代萘咪酮类衍生物.该策略具有良好的官能团兼容性和底物普适性,能够以较高的收率得到目标卤化物,并能为高效制备具有良好生物活性的萘咪酮类衍生物提供新的合成路线.A method for the efficient preparation ofα-halogenated nafimidone derivatives is reported,utilizing CuI as catalyst and cheap potassium halide as halogen source.This strategy demonstrates excellent functional group compatibility and substrate versatility,allowing for the synthesis of the target halides in high yields.This new synthetic route offers an efficient approach to preparing nafimidone derivatives with potential biological activities.

关 键 词：C(sp~3)-H活化 氯化反应 溴化反应 萘咪酮 

分 类 号：TQ317[化学工程—高聚物工业]