髓源性抑制细胞参与自身免疫性疾病发展的调控  

Myeloid-derived suppressor cells participate in regulation of development of autoimmune diseases

作　　者：程飘涛 宫首航 孔平 李陈诚 郭曹培 彭笳宸 CHENG Piaotao;GONG Shouhang;KONG Ping;LI Chencheng;GUO Caopei;PENG Jiachen(Affiliated Hospital of Zunyi Medical University,Zunyi 563000,China)

机构地区：[1]遵义医科大学附属医院,遵义563000

出　　处：《中国免疫学杂志》2024年第12期2666-2675,共10页Chinese Journal of Immunology

基　　金：国家自然科学基金项目(81760400)。

摘　　要：髓源性抑制细胞(MDSCs)是一组具有免疫抑制作用的异质性未成熟骨髓细胞群。近年来,随着深入研究MDSCs的免疫抑制活性,MDSCs在自身免疫性疾病(AD)中备受关注。在AD中,MDSCs明显活化扩增且通过不同的机制调节机体的免疫应答,进而对疾病起到促进或抑制发展的作用。因此,探究MDSCs在AD中的具体作用和机制研究,才可以更好地阐明MDSCs并为AD治疗的临床转化提供积极的作用。本文对MDSCs的免疫抑制机制及其在不同AD中的作用进行综述。Myeloid-derived suppressor cells(MDSCs)are heterogeneous immature bone marrow cells with immunosuppressive effects.In recent years,with the in-depth study of the immunosuppressive activity of MDSCs,MDSCs have attracted much attention in autoimmune diseases autoimmune disease(AD).In AD,MDSCs are significantly activated and amplified and regulate the immune response of the body through different mechanisms,thus promoting or inhibiting the development of the disease.Therefore,only by deepening the research on the specific role and mechanism of MDSCs in autoimmune diseases can we better clarify MDSCs and provide a positive role for the clinical transformation of the treatment of AD.This paper reviews the immunosuppressive mechanism of MDSCs and their roles in different AD.

关 键 词：髓源性抑制细胞 自身免疫性疾病 免疫抑制 T细胞 

分 类 号：R593.2[医药卫生—内科学]