蠕虫感染影响宿主胆汁酸代谢的研究进展  

Research advances on the effects of helminth infection on bile acid metabolism

作　　者：张莹 王玉桂 时志琪 王帅[1] ZHANG Ying;WANG Yugui;SHI Zhiqi;WANG Shuai(State Key Laboratory for Animal Disease Control and Prevention/College of Veterinary Medicine,Lanzhou University/Lanzhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Lanzhou 730046,Gansu,China)

机构地区：[1]中国农业科学院兰州兽医研究所,兰州大学动物医学与生物安全学院动物疫病防控全国重点实验室,甘肃兰州730046

出　　处：《中国寄生虫学与寄生虫病杂志》2024年第5期648-652,共5页Chinese Journal of Parasitology and Parasitic Diseases

基　　金：“十四五”国家重点研发计划(2022YFD1800200);甘肃省科技重大专项(22ZD6NA001)。

摘　　要：寄生蠕虫在全球广泛分布,对畜牧业和公共卫生均有较大影响。蠕虫感染可影响宿主的代谢、免疫等过程,最新研究表明蠕虫感染后会显著改变宿主的胆汁酸代谢,进而直接或间接地影响宿主健康和免疫稳态。本文就线虫、绦虫和吸虫对宿主胆汁酸代谢影响的研究进展进行综述,以期为相关疾病的诊断、治疗和预防提供新的研究思路。Parasitic helminths are widely distributed globally and have a significant impact on animal husbandry and public health.Helminth infection can affect metabolic and immune processes in the host.The latest research shows that helminth infection significantly alters host bile acid metabolism,which in turn directly or indirectly affects the host's health and immune homeostasis.This article reviews the advances in research on the effects of nematodes,tapeworms,and flukes on host bile acid metabolism to provide new research ideas for the diagnosis,treatment,and prevention of related diseases.

关 键 词：蠕虫感染 胆汁酸 代谢 

分 类 号：R532[医药卫生—内科学]