宿主细胞自主免疫抗弓形虫的研究进展  

Research advances on host cell-autonomous immunity against Toxoplasma gondii

作　　者：李仕毓 李静 陆绍红 郑斌 LI Shiyu;LI Jing;LU Shaohong;ZHENG Bin(School of Basic Medicine and Forensics,Hangzhou Medical College,Hangzhou 310000,Zhejiang,China)

机构地区：[1]杭州医学院基础医学与法医学院,浙江杭州310000

出　　处：《中国寄生虫学与寄生虫病杂志》2024年第5期653-658,663,共7页Chinese Journal of Parasitology and Parasitic Diseases

基　　金：浙江省卫生高层次人才工程-医坛新秀(2020-35);浙江省重点研发项目(2022C031109)。

摘　　要：刚地弓形虫是人类和动物最常见的感染性病原体之一,可引起人兽共患弓形虫病。该病可对人类健康和畜牧业生产造成严重危害。细胞自主免疫是单个细胞内部发生的固有免疫应答,旨在限制入侵细胞内的病原体(如细菌、病毒、寄生虫等)的复制与传播。弓形虫感染宿主细胞后,细胞自主免疫主要由干扰素诱导的吲哚胺2,3-二氧化酶、诱导型一氧化氮合酶、三磷酸鸟苷酶家族、自噬相关蛋白和泛素化产物进行调控,在宿主细胞抗弓形虫过程中发挥重要作用。本文对宿主细胞自主免疫抗弓形虫的研究进展进行综述,以期为弓形虫病的预防和治疗提供新的方向。Toxoplasma gondii isone of the most common infectious agents in humans and animals,causing zoonotic toxoplasmosis,which poses a serious hazard to human health and animal husbandry production.Cell-autonomous immunity is an intrinsic immune response that occurs within individual cells to limit the replication and spread of pathogens(e.g.,bacteria,viruses,parasites,etc.) that invade the cells.After infection of host cells by T.gondii,cell-autonomous immunity is mainly regulated by interferon-induced indoleamine 2,3-dioxygenase(IDO),inducible nitric oxide synthase(iNOS),GTPase family enzymes,autophagy-related proteins,and ubiquitylation products,all of which play an important role in host cell resistance to T.gondii.In this paper,we reviewed the research advances on the autonomous immune response of host cell against T.gondii,aiming to provide new directions for the prevention and treatment of toxoplasmosis.

关 键 词：刚地弓形虫 细胞自主免疫 Γ干扰素 

分 类 号：R382.5[医药卫生—医学寄生虫学]