北京怀柔地区单中心202例肾活检患者的临床和病理分析  

Clinical and pathological analysis of 202 patients undergoing renal biopsy at a single center in Huairou district, Beijing

作　　者：王艳非 Wang Yanfei(Department of Nephrology,Beijing Huairou Hospital,Beijing 101400,China)

机构地区：[1]北京怀柔医院肾内科,北京101400

出　　处：《国际泌尿系统杂志》2024年第6期1105-1109,共5页International Journal of Urology and Nephrology

摘　　要：目的分析北京怀柔地区单中心肾活检患者的临床与病理特点。方法选取2017年1月至2022年1月在本院经皮肾穿刺活检的202例患者的临床和病理资料,根据性别将患者分为男性组(125例)和女性组(77例)。根据联合国世界卫生组织对年龄的划分标准将其分为青年组(14~44岁,63例)、中年组(45~59岁,69例)和老年组(≥60岁,70例)。根据估算肾小球滤过率(eGFR)水平将其分为A组[eGFR≥90 mL·(min·1.73 m^(2))^(-1)]、B组[60~89 mL·(min·1.73 m^(2))^(-1)]、C组[30~59 mL·(min·1.73 m^(2))^(-1)]、D组[15~29 mL·(min·1.73 m^(2))^(-1)]和E组[<15 mL·(min·1.73 m^(2))^(-1)]。分析各组患者的病理类型关系。结果在原发性肾小球疾病(PGD)中两组患者的各病理类型比较,差异无统计学意义(P>0.05)。在继发性肾小球疾病(SGD)中两组患者的各病理类型比较,差异无统计学意义(P>0.05)。在肾小管间质性疾病(TID)中,急性肾小管坏死3例,亚急性间质性肾炎2例,慢性肾小管间质性肾病5例。膜性肾病主要见于中老年组患者,构成比随年龄增加而增加,差异有统计学意义(均P<0.05)。IgA肾病主要见于青年组、中年组患者。肾小球轻微病变在青年组患者中最为常见,差异有统计学意义(P<0.05)。C、D、E组中IgA肾病出现肾功能损伤的比例最高,占24.14%,其次是糖尿病肾病,占13.79%,系膜增生性肾小球肾炎出现肾功能损伤比例为10.34%,慢性肾小管间质性肾病为8.62%。结论原发性肾小球疾病仍然是肾活检患者中最常见的病理类型,其中膜性肾病最为常见,糖尿病肾病已经成为最常见的继发性肾小球疾病。随着年龄增长,IgA肾病、肾小球轻微病变的检出率下降,而膜性肾病的检出率增加。ObjectiveTo evaluate the clinical and pathological features of patients undergoing renal biopsy at a single center in the department of nephrology of Beijing Huairou Hospital.MethodsClinical and pathological data of 202 patients undergoing percutaneous renal biopsy in our hospital from January 2017 to January 2022 were selected,and the patients were divided into male group(125 cases)and female group(77 cases)according to gender.According to the World Health Organization′s age classification criteria,it is divided into young group(14-44 years old,63 cases),middle-aged group(45-59 years old,69 cases)and old group(≥60 years old,70 cases).According to the estimated glomerular filtration rate(eGFR)level,they were divided into group A[eGFR≥90 mL·(min·1.73 m^(2))^(-1)],group B[60-89 mL·(min·1.73 m^(2))^(-1)],group C[30-59 mL·(min·1.73 m^(2))^(-1)]and group D[15-29 mL·(min·1.73 m^(2))^(-1)]and group E[<15 mL·(min·1.73 m^(2))^(-1)].The relationship between pathological types of patients in each group was analyzed.ResultsThere was no significant difference in pathological types between the two groups in primary glomerular diseases(PGD)(P>0.05).There was no significant difference in the pathological types of secondary glomerular diseases(SGD)between the two groups(P>0.05).In renal tubulointerstitial disease(TID),there were 3 cases of acute tubular necrosis,2 cases of subacute interstitial nephritis and 5 cases of chronic tubular interstitial nephropathy.Membranous nephropathy was mainly seen in middle-aged and elderly patients,and the proportion of membranous nephropathy increased with the increase of age,the difference was statistically significant(all P<0.05).IgA nephropathy was mainly seen in young and middle-aged patients,and minor glomerular lesions were the most common in young patients,with statistical significance(P<0.05).In group C,D and E,IgA nephropathy had the highest proportion of renal damage,accounting for 24.14%,followed by diabetic nephropathy,accounting for 13.79%,mesangial proliferative gl

关 键 词：活组织检查 针吸 肾 北京 

分 类 号：R692[医药卫生—泌尿科学]