2012—2020年扬州市利福平耐药肺结核流行特征及治疗转归分析  

Analysis of the epidemic characteristics and treatment outcomes of rifampicin-resistant pulmonary tuberculosis in Yangzhou City from 2012 to 2020

作　　者：王慧 李锦成 卜春红 王磊 赵倩颖 竺丽梅[2] Wang Hui;Li Jincheng;Bo Chunhong;Wang Lei;Zhao Qianying;Zhu Limei(Chronic Infectious Disease Control Department,Yangzhou Prefectural Center for Disease Control and Prevention,Yangzhou225000,China)

机构地区：[1]扬州市疾病预防控制中心慢性传染病防制科,扬州225000 [2]江苏省疾病预防控制中心慢性传染病防制所,南京210000

出　　处：《中华预防医学杂志》2024年第11期1679-1683,共5页Chinese Journal of Preventive Medicine

基　　金：江苏省卫生健康委科研项目(ZDA2020022)。

摘　　要：从中国疾病预防控制信息系统中获取2012—2020年扬州市利福平耐药肺结核(RR-PTB)患者病例资料, 采用χ^(2)检验分析RR-PTB患者流行特征, 结果显示, 2012—2020年扬州市RR-PTB患者年均登记发病率0.57/10万, 各年份登记发病率差异有统计学意义(χ^(2)=29.326, P<0.001), 复治患者占比(64.8%)高于初治患者(35.2%, χ^(2)=50.593, P<0.001)。男性登记发病率(0.91/10万)高于女性(0.24/10万, χ^(2)=80.566, P<0.001)。年龄分布显示, 患者登记发病率以≥60岁年龄段最高(0.96/10万), 0~<45岁年龄段最低(0.31/10万, χ^(2)=55.853, P<0.001)。2012—2020年宝应县RR-PTB患者登记数(44例)最多, 登记发病率(0.64/10万)仅次于广陵区(0.98/10万), 而2016—2020年与2012—2015年相比, 宝应县RR-PTB患者登记发病率亦显著增加(P=0.001)。采用logistic回归分析RR-PTB患者的治疗转归相关因素, 结果显示, 患者年龄≥60岁和复治分类为影响RR-PTB患者成功治疗的危险因素(P<0.05)。综上, 扬州市RR-PTB疫情防控的重点人群为男性、≥60岁人群、复治患者和宝应县地区的居民。Information on patients with rifampicin-resistant pulmonary tuberculosis(RR-PTB)in Yangzhou City from 2012 to 2020 was obtained from the Information System of the Chinese Center for Disease Control and Prevention.The epidemic characteristics of RR-PTB patients were analyzed by usingχ^(2) test.The average annual registered incidence rate of RR-PTB patients in Yangzhou City from 2012 to 2020 was 0.57/100000,and the difference between the registered incidence rates in each year was statistically significant(χ^(2)=29.326,P<0.001).The proportion of re-treated patients(64.8%)was higher than that of newly treated patients(35.2%,χ^(2)=50.593,P<0.001).The registered incidence rate in males(0.91/100000)was higher than that in females(0.24/100000,χ^(2)=80.566,P<0.001).The age distribution showed that the highest incidence rate was in the age group≥60 years(0.96/100000)and the lowest was in the age group 0-<45 years(0.31/100000,χ^(2)=55.853,P<0.001).From 2012 to 2020,Baoying County had the largest number of registered RR-PTB patients(44 cases),and its registered incidence rate(0.64/100000)was only lower than that of Guangling District(0.98/100000).The registered incidence rate of RR-PTB patients in Baoying County during 2016—2020 also increased significantly compared to 2012—2015(P=0.001).Logistic regression was used to analyze the factors related to the treatment outcome of RR-PTB patients.The results showed that patients aged≥60 years and those classified as the re-treatment were risk factors for successful treatment of RR-PTB patients(P<0.05).In summary,males,people aged≥60 years,patients classified as the re-treatment,and residents of Baoying County should be the key populations for RR-PTB epidemic prevention and control in Yangzhou City.

关 键 词：肺结核 利福平耐药 流行特征 治疗转归 监测 

分 类 号：R521[医药卫生—内科学] R181.3[医药卫生—临床医学]