浙麦冬化学成分、药理作用及分子生药学研究进展  

Research progress on chemical constituents,pharmacological effects and molecular pharmacognosy of Zhejiang Ophiopogonis Radix

作　　者：高晗 胡栋斌 李果[2] 麻光磊 范骁辉[1,2] GAO Han;HU Dong-bin;LI Guo;MA Guang-lei;FAN Xiao-hui(College of Pharmaceutical Sciences,Zhejiang University,Hlangzhou 310058,China;Future Health Laboratory,Innovation Center of Yangtze River Delta,Zhejiang University,Jiaxing 314102,China)

机构地区：[1]浙江大学药学院,浙江杭州310058 [2]浙江大学长三角智慧绿洲创新中心未来健康实验室,浙江嘉兴314102

出　　处：《中国中药杂志》2024年第21期5805-5816,共12页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金联合基金重点项目(U23A20513);中央高校基本科研业务费专项(226-2024-00149)。

摘　　要：麦冬根据道地产区不同素有浙麦冬和川麦冬之分,其中浙麦冬是著名的“浙八味”之一,具有养阴生津、润肺清心之功效。麦冬富含甾体皂苷类、高异黄酮类、萜类和多糖类等有效成分,具有保护心脑血管、抗肿瘤、降血糖、抗炎及免疫调节等药理活性。研究表明不同产区间麦冬的化学品质和药用功效存在差异,而目前围绕麦冬的概述多以川麦冬为对象,尚未有针对浙麦冬的系统性归纳。该研究从化学成分、药理作用及分子生药学等方面对浙麦冬进行综述,以期助力全局理解浙麦冬高品质所蕴含的成分集群和效用网络,为后续深入探讨浙产麦冬道地性形成的科学内涵提供参考。Ophiopogonis Radix,a well-known Chinese herb,is dominantly cultivated in Zhejiang and Sichuan provinces,with the Zhejiang Ophiopogonis Radix acting as one of the eight Zhejiang-based traditional medical materials.Phytochemical studies have shown that Ophiopogonis Radix is rich in steroidal saponins,homoisoflavonoids,terpenoids,and polysaccharides,which collectively confer it with cardiovascular protection,anti-inflammation,anticancer,antioxidation,and immune regulation activities.Studies also show that Ophiopogonis Radix originated from Zhejiang and Sichuan is discriminated in both chemical components and clinical efficacy,while the existing reviews of Ophiopogonis Radix appear to pose a particular focus on Sichuan species,but not for Zhejiang origin.This article systematically summarizes the structures and bioactivities of the compounds sourced from Zhejiang Ophiopogonis Radix as well as its molecular pharmacognosy and it will set the stage for a comprehensive understanding of geo-authentic Ophiopogonis Radix.

关 键 词：浙麦冬 化学成分 药理作用 分子生药学 甾体皂苷 高异黄酮 

分 类 号：R284.1[医药卫生—中药学] R285[医药卫生—中医学]