苍术倍半萜类化合物生物合成的研究进展  

Research progress on biosynthesis of sesquiterpenoids in Atractylodes lancea

作　　者：冯铃芳 王升[1,2] 张成才 王红阳 郭秀芝 曹也 张逸风 郭兰萍[1,2] FENG Ling-fang;WANG Sheng;ZHANG Cheng-cai;WANG Hong-yang;GUO Xiu-zhi;CAO Ye;ZHANG Yi-feng;GUO Lan-ping(State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs,National Resource Center for Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China;Key Laboratory of Biology and Cultivation of Herb Medicine,Ministry of Agriculture and Rural Affairs,Bejing 100700,China)

机构地区：[1]中国中医科学院中药资源中心道地药材品质保障与资源持续利用全国重点实验室,北京100700 [2]农业农村部中药材生物学与栽培重点实验室,北京100700

出　　处：《中国中药杂志》2024年第21期5829-5834,共6页China Journal of Chinese Materia Medica

基　　金：国家重点研发计划项目(2023YFC3503801);国家中医药管理局中医药创新团队及人才支持计划项目(ZYYCXTD-D-202005);中国中医科学院科技创新工程项目(CI2021A03903,CI2021A03905,CI2021B013,CI2023E002)。

摘　　要：中药苍术为菊科草本植物苍术Atractylodes lancea的干燥根茎,具有燥湿健脾、祛风散寒、明目等功效。苍术中的倍半萜类化合物为其发挥临床疗效的主要活性成分,包括苍术酮、β-桉叶醇、茅术醇等,具有抗炎、抗菌、抗病毒、保肝等多种药理作用。该文聚焦苍术倍半萜类化合物的生物合成,汇总了道地产区与非道地产区主要活性成分含量比例,详细阐述了其生物合成途径相关基因研究进展,并系统整理了影响其积累的生物和非生物因素,旨在为解析苍术倍半萜类化合物生物合成机制和开发高品质苍术药材提供参考。The traditional Chinese medicine Atractlodis Rhizoma is the dried rhizome of the Asteraceae herbal plant Atractylodes lancea,and it has the functions of drying dampness and strengthening the spleen,removing wind and dissipating cold,and brightening the eyes.The sesquiterpenoids in A.lancea are the main ingredients of its pharmacological activities in clinical practice,including atractylone,β-eudesmol,and hinesol,which possess anti-inflammation,antibacterial,antiviral,and hepatoprotective effects.This study focused on the biosynthesis of sesquiterpenoids in A.lancea,summarized the proportion of the main active ingredients in A.lancea from the genuine region and the non-genuine region,elaborated on the research progress of genes related to biosynthesis pathways,and systematically sorted out the biotic and abiotic factors affecting their biosynthesis,so as to provide a theoretical basis for further research on the biosynthetic mechanism of sesquiterpenoids in A.lancea and development of high-quality medicinal materials of A.lancea.

关 键 词：苍术 倍半萜类化合物 生物合成 影响因素 

分 类 号：R284.3[医药卫生—中药学]