甘露消毒丹联合苦黄散治疗手足口病肺脾湿热蕴毒证的临床效果  

Clinical effect of Ganlu Xiaodu Dan combined with Kuhuang San in the treatment of hand,foot and mouth disease with lung spleen damp heat toxin accumulation syndrome

作　　者：钟斌 陈青[1] 李曦 李明明 廖泽辉 梁静[1] 陈婕 唐兰 苏信镭 ZHONG Bin;CHEN Qing;LI Xi;LI Mingming;LIAO Zehui;LIANG Jing;CHEN Jie;TANG Lan;SU Xinlei(Department of Pediatrics,Wuzhou Traditional Chinese Medicine Hospital Affiliated to Guangxi University of Chinese Medicine,Guangxi Zhuang Autonomous Region,Wuzhou 543002,China)

机构地区：[1]广西中医药大学附属梧州市中医医院儿科,广西壮族自治区梧州市543002

出　　处：《临床合理用药杂志》2024年第34期33-36,共4页Chinese Journal of Clinical Rational Drug Use

基　　金：广西壮族自治区中医药管理项目(GZSY22-86)。

摘　　要：目的观察甘露消毒丹联合苦黄散治疗手足口病肺脾湿热蕴毒证的临床效果。方法选取2022年1月—2023年12月广西中医药大学附属梧州市中医医院儿科住院及门诊诊断为手足口病肺脾湿热蕴毒证患儿200例,采用随机数字表法分为研究组和对照组,各100例。对照组予常规西医治疗,研究组在对照组基础上予甘露消毒丹联合苦黄散治疗,2组疗程均为5~7 d。比较2组临床效果、体温恢复正常时间、皮疹消退时间,治疗前后肝功能指标[丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、总胆红素(TBil)]、肾功能指标[尿素氮(BUN)、肌酐(Cr)]、空腹血糖(FPG)、心肌酶[肌酸激酶(CK)、乳酸脱氢酶(LDH)、α-羟丁酸脱氢酶(α-HBD)、肌酸激酶同工酶(CK-MB)]水平及血常规[白细胞计数(WBC)、淋巴细胞绝对值(LYM)、中性粒细胞绝对值(GRAN)、血小板(PLT)]。结果研究组总有效率为86.00%,高于对照组的74.00%(χ^(2)=4.500,P=0.034);研究组体温恢复正常时间及皮疹消退时间均短于对照组(P<0.01)。治疗5~7 d后,2组ALT、AST、TBil水平低于治疗前,且研究组ALT、AST水平低于对照组(P<0.05或P<0.01),2组TBil水平比较差异无统计学意义(P>0.05)。治疗前后,2组BUN、Cr、FPG水平组内、组间比较差异均无统计学意义(P>0.05)。治疗5~7 d后,2组CK及WBC水平低于治疗前,且研究组低于对照组(P<0.01);2组LDH、α-HBD、CK-MB及LYM、GRAN、PLT组内、组间比较差异均无统计学意义(P>0.05)。结论甘露消毒丹联合苦黄散应用于手足口病肺脾湿热蕴毒证治疗中可提高疗效,缩短患儿体温恢复正常时间、皮疹消退时间,改善患儿肝功能。Objective To observe the clinical effect of Ganlu Xiaodu Dan combined with Kuhuang San in the treatment of hand,foot and mouth disease with lung spleen damp heat toxin accumulation syndrome.Methods A total of 200 children with hand,foot and mouth disease with lung spleen damp heat toxin accumulation syndrome in the inpatient and outpatient departments of the Department of Pediatrics,Wuzhou Traditional Chinese Medicine Hospital Affiliated to Guangxi University of Chinese Medicine from January 2022 to December 2023 were selected and randomly divided into the study group and the control group,with 100 cases in each group.The control group was treated with conventional western medicine,while the study group was treated with Ganlu Xiaodu Dan combined with Kuhuang San on the basis of the control group.The course of treatment for both groups was 5 to 7 days.The clinical effect,the time of body temperature returning to normal,the time of rash resolution,the liver function indexes(ALT,AST,TBil),renal function indexes(BUN,Cr),FPG,myocardial enzymes(CK,LDH,α-HBD,CK-MB)levels and blood routine(WBC,LYM,GRAN,PLT)before and after treatment were compared between the two groups.Results The total effective rate of the study group was 86.00%,which was higher than 74.00%of the control group(χ^(2)=4.500,P=0.034).The time of body temperature returning to normal and the time of rash resolution in the study group were shorter than those in the control group(P<0.01).After treatment,the levels of ALT,AST and TBil in the two groups were lower than those before treatment,and the levels of ALT and AST in the study group were lower than those in the control group(P<0.05 or P<0.01).There was no significant difference in the levels of TBil between the two groups(P>0.05).Before and after treatment,there was no significant difference in BUN,Cr and FPG levels between the two groups(P>0.05).After treatment,the levels of CK and WBC in the two groups were lower than those before treatment,and those in the study group were lower than those in the co

关 键 词：手足口病 肺脾湿热蕴毒证 甘露消毒丹 苦黄散 肝功能 肾功能 

分 类 号：R272[医药卫生—中医儿科学]