2-吡啶甲酰胺脱水反应工艺研究  

Investigation of Dehydration Reaction Process of 2-Picolinamide

作　　者：韩亚彤 徐伟斌 薛琛 成有为[1,2] HAN Yatong;XU Weibin;XUE Chen;CHENG Youwei(College of Chemical and Biological Engineering,Zhejiang University,Hangzhou 310058,China;Institute of Zhejiang University-Quzhou,Quzhou 324000,China)

机构地区：[1]浙江大学化学工程与生物工程学院,浙江杭州310058 [2]浙江大学衢州研究院,浙江衢州324000

出　　处：《化学反应工程与工艺》2024年第5期403-410,共8页Chemical Reaction Engineering and Technology

摘　　要：在CO_(2)和甲醇直接反应制备碳酸二甲酯的体系中,加入脱水剂2-氰基吡啶可以大大提高产物碳酸二甲酯(DMC)的收率,但同时会等摩尔消耗脱水剂2-氰基吡啶生成2-吡啶甲酰胺。本研究以CeO_(2)为催化剂,2-吡啶甲酰胺为原料,氨气为带水剂,考察了反应温度、反应物浓度、氨气流量、催化剂浓度等因素对2-吡啶甲酰胺脱水反应的影响,确定了催化反应较优的运行条件。结果表明:当反应温度为260℃,反应以氨气作为带水剂、二苯醚作为溶剂,反应时间为3 h,反应催化剂与反应物的质量比为0.1:1的优化条件时,2-吡啶甲酰胺转化率大于90%,2-氰基吡啶的收率接近70%。Adding the dehydrating agent 2-cyanopyridine to the system for the direct preparation of dimethyl carbonate(DMC)from CO_(2)and methanol can greatly improve the yield of the product.The disadvantage is that the dehydrating agent 2-cyanopyridine will be consumed equimolar and 2-picolinamide will be generated while preparing DMC.In this paper,CeO_(2)was used as a catalyst,2-picolinamide was used as raw material,and ammonia gas was used as water entraining agent.The effects of reaction temperature,reactant concentration,ammonia flow rate,and catalyst concentration on the dehydration of 2-picolinamide were investigated.The optimal operating conditions of the catalytic reactant were determined as follows:reaction temperature 260℃,ammonia gas as water entraining agent,diphenyl ether as solvent,and reaction time 3 h,The mass ratio of reaction catalyst to reactant was 0.1:1.Under these reaction conditions,the conversion of 2-picolinamide was greater than 90%,and the yield of 2-cyanopyridine was close to 70%.

关 键 词：2-吡啶甲酰胺 2-氰基吡啶 脱水 二氧化铈 

分 类 号：O626[理学—有机化学]