骨类器官的构建、评价与应用专家共识(2024版)  

Expert consensus on the construction,evaluation and application of bone organoids(version 2024)

作　　者：王健 白龙 陈晓 刘媛媛[3] 刘国辉[4] 施忠民[5] 林开利[6] 何创龙[7] 王靖[8] 耿振[2] 施威扬 张文财[10] 周凤金 杨强[12] 杨立利 王志伟 林浩东 张云飞 魏富鑫 陈伟[18] 崔文国 罗飞 费军 谢辉[22] 罗剑 吴成铁[24] 刘宣勇 郑玉峰[25] 刘昌胜 苏佳灿 中国老年学和老年医学学会老年病学分会骨科专家委员会 中华医学会骨科学分会青年骨质疏松学组 中国医师协会骨科医师分会骨质疏松学组 上海中西医结合学会骨质疏松专业委员会 Wang Jian;Bai Long;Chen Xiao;Liu Yuanyuan;Liu Guohui;Shi Zhongmin;Lin Kaili;He Chuanglong;Wang Jing;Geng Zhen;Shi Weiyang;Zhang Wencai;Zhou Fengjin;Yang Qiang;Yang Lili;Wang Zhiwei;Lin Haodong;Zhang Yunfei;Wei Fuxin;Chen Wei;Cui Wenguo;Luo Fei;Fei Jun;Xie Hui;Luo Jian;Wu Chengtie;Liu Xuanyong;Zheng Yufeng;Liu Changsheng;Su Jiacan;Orthopedic Expert Committee of Geriatric Branch of Chinese Association of Gerontology and Geriatrics;Youth Osteoporosis Group of Orthopedic Branch of Chinese Medical Association;Osteoporosis Group of Orthopedic Surgeon Branch of Chinese Medical Doctor Association;Osteoporosis Committee of Shanghai Association of Integrated Traditional Chinese and Western Medicine(Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China;Institute of Translational Medicine,Shanghai University,Shanghai 200444,China;School of Mechatronics Engineering and Automation,Shanghai University,Shanghai 200444,China;Union Hospital Affiliated to Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;Sixth People′s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200233,China;Ninth People′s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China;College of Biological and Medical Engineering,Donghua University,Shanghai 201620,China;School of Materials Science and Engineering,East China University of Science and Technology,Shanghai 200237,China;College of Marine Life Sciences,Ocean University of China,Qingdao 266003,China;First Affiliated Hospital of Jinan University,Guangzhou 510630,China;Affiliated Honghui Hospital of Xi′an Jiaotong University,Xi′an 710054,China;Tianjin Hospital,Tianjin 300211,China;Second Affiliated Hospital of Naval Medical University,Shanghai 200003,China;Third Affiliated Hospital of Naval Medical University,Shanghai 200433,China;Shanghai General Hospital,Shanghai 200080,China;Tangdu Hospital of Air Force Medical University,Xi′an 710038,China;Sev

机构地区：[1]上海交通大学医学院附属新华医院,上海200092 [2]上海大学转化医学研究院,上海200444 [3]上海大学机电工程与自动化学院,上海200444 [4]华中科技大学同济医学院附属协和医院,武汉430022 [5]上海交通大学医学院附属第六人民医院,上海200233 [6]上海交通大学医学院附属第九人民医院,上海200011 [7]东华大学生物与医学工程学院,上海201620 [8]华东理工大学材料科学与工程学院,上海200237 [9]中国海洋大学海洋生命学院,青岛266003 [10]暨南大学附属第一医院,广州510630 [11]西安交通大学附属红会医院,西安710054 [12]天津市天津医院,天津300211 [13]海军军医大学第二附属医院,上海200003 [14]海军军医大学第三附属医院,上海200433 [15]上海市第一人民医院,上海200080 [16]空军军医大学唐都医院,西安710038 [17]中山大学附属第七医院,深圳518107 [18]河北医科大学第三医院,石家庄050051 [19]上海交通大学医学院附属瑞金医院,上海200025 [20]陆军军医大学第一附属医院,重庆400038 [21]陆军军医大学陆军特色医学中心,重庆400042 [22]中南大学湘雅医院,长沙410008 [23]同济大学医学院,上海200092 [24]中国科学院上海硅酸盐研究所,上海200050 [25]北京大学材料科学与工程学院,北京100871 [26]上海大学,上海200444 [27]不详

出　　处：《中华创伤杂志》2024年第11期974-986,共13页Chinese Journal of Trauma

基　　金：国家重点研发计划(2022YFB3804300);国家自然科学基金(82230071);上海申康研究型医师创新转化能力培训项目(SHDC2023CRT013);上海市创新医疗器械应用示范项目(23SHS05700)。

摘　　要：骨类器官能模仿骨组织复杂结构和功能,是类器官研究前沿技术,在骨疾病建模、骨损伤修复和药物筛选领域展现出巨大应用潜力。尽管当前骨类器官构建在矿化、骨髓、骨小梁、骨痂及编织骨等骨组织功能结构的研究中取得一定进展,但目前骨类器官研究存在诸多问题,如构建策略缺乏规范、评价缺少统一标准等,限制了其进一步推广应用。为规范骨类器官研究,由中国老年学和老年医学学会老年病学分会骨科专家委员会、中华医学会骨科学分会青年骨质疏松学组、中国医师协会骨科医师分会骨质疏松学组和上海中西医结合学会骨质疏松专业委员会组织有关专家,基于循证证据,制订《骨类器官的构建、评价与应用专家共识(2024版)》,共提出17条推荐意见,旨在规范骨类器官研究和临床应用,提升其在科研和临床应用中的价值。Bone organoids can simulate the complex structure and function of the bone tissues,which makes them a frontier technology in organoid researches.Bone organoids show a tremendous potential of applications in bone disease modeling,bone injury repair,and medicine screening.Although advancements have been made so far in constructing bone organoids with functional structures like mineralization,bone marrow,trabecular bone,callus,woven bone,etc,the researches in this field are confronted with numerous challenges such as lack of standardized construction strategies and unified evaluation criteria,which limits their further promotion and application.To standardize researches in bone organoids,the Orthopedic Expert Committee of Geriatric Branch of Chinese Association of Gerontology and Geriatrics,the Youth Osteoporosis Group of Orthopedic Branch of Chinese Medical Association,the Osteoporosis Group of Orthopedic Surgeon Branch of Chinese Medical Doctor Association,and the Osteoporosis Committee of Shanghai Association of Integrated Traditional Chinese and Western Medicine organized related experts to formulate Expert consensus on the construction,evaluation,and application of bone organoids(version 2024)based on an evidence‑based approach.A total of 17 recommendations were put forth,aiming to standardize researches and clinical applications of bone organoids and enhance their value in scientific research and clinical practice.

关 键 词：骨疾病 类器官 干细胞 伦理 

分 类 号：R318[医药卫生—生物医学工程]