机械敏感通道Piezo1对创伤性关节炎软骨细胞调控机制的研究进展  

Mechanism of the mechanosensitive channel Piezo1 regulating chondrocytes in post‑traumatic osteoarthritis:a review

作　　者：袁功武 李志钢 柯烯 刘曦明 Yuan Gongwu;Li Zhigang;Ke Xi;Liu Ximin(Department of Orthopedics,Hubei Provincial Hospital of Integrated Traditional Chinese&Western Medicine,Wuhan 430015,China;Department of Orthopedics,General Hospital of Central Theater Command of PLA,Wuhan 430070,China;College of Acupuncture and Orthopedics,Hubei University of Chinese Medicine,Wuhan 430065,China)

机构地区：[1]湖北省中西医结合医院骨科,武汉430015 [2]中国人民解放军中部战区总医院骨科,武汉430070 [3]湖北中医药大学针灸骨伤学院,武汉430065

出　　处：《中华创伤杂志》2024年第11期1040-1048,共9页Chinese Journal of Trauma

基　　金：湖北省卫生健康委员会转化医学项目(WJ2021ZH0010);武汉市2023年度知识创新专项(2023020201010179)。

摘　　要：创伤性关节炎(PTOA)是由关节损伤引发的一种慢性退行性关节疾病,其中异常机械应力刺激是其重要发生机制之一。目前,即使手术治疗PTOA也难以完全修复关节软骨,尚缺乏有效的治疗方法。软骨细胞作为PTOA病理过程的主要细胞类型之一,对机械信号表现出极高的敏感性。机械敏感离子通道Piezo1在感受细胞外力和机械刺激的过程中具有重要功能,并通过调节关节软骨细胞对机械应力的响应,在PTOA中发挥关键作用。因此,明确Piezo1通道对PTOA软骨细胞的调控机制,对探寻新的治疗策略具有重要意义。为此,笔者就Piezo1通道对PTOA软骨细胞调控机制的研究进展进行综述,为PTOA的发生机制研究和治疗提供参考。Post⁃traumatic osteoarthritis(PTOA)is a chronic degenerative joint disease caused by joint injury and abnormal mechanical stress stimulation is one of its key mechanisms.Currently,it is difficult to repair the articular cartilage completely even with surgical treatment and there is a lack of effective treatments for PTOA.Chondrocytes,one of the primary cell types involved in the pathogenic process of PTOA,are highly sensitive to mechanical signals.The mechanosensitive ion channel Piezo1 serves the important functions of sensing external forces and mechanical stimuli and plays a crucial role in PTOA by regulating chondrocytes′responses to mechanical stress.Therefore,its essential to understand the mechanisms of the Piezo1 channel in regulating PTOA chondrocytes in exploring new therapeutic strategies.To this end,the authors reviewed the research progress on the regulatory mechanisms of the Piezo1 channel on PTOA chondrocytes,aiming to provide a reference for future studies on PTOA mechanisms and treatment options.

关 键 词：骨关节炎 离子通道 软骨细胞 应力 物理 

分 类 号：R684.3[医药卫生—骨科学]