中国人脑组织库协作联盟标准化操作方案第2版  

Standardized operational protocol for the China Human Brain Bank Consortium(2nd edition)

作　　者：王雪 陈震 吴娟利 王乃利[4] 张迪[4] 杜鹃[5] 余亮[1] 段婉茹 刘芃昊[6] 张翰林 黄灿 朴月善 竺可青[2] 包爱民 章京 沈逸[2,3] 马超 仇文颖 钱晓菁[1] WANG Xue;CHEN Zhen;WU Juan-li;WANG Nai-li;ZHANG Di;DU Juan;YU Liang;DUAN Wan-ru;LIU Peng-hao;ZHANG Han-lin;HUANG Can;PIAO Yue-shan;ZHU Ke-qing;BAO Ai-min;ZHANG Jing;SHEN Yi;MA Chao;QIU Wen-ying;QIAN Xiao-jing(National Human Brain Bank for Development and Function,Department of Human Anatomy,Histology and Embryology,Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing 100005,China;National Health and Disease Human Brain Tissue Resource Center,Hangzhou 310058,China;School of Brain Science and Brain Medicine,Zhejiang University School of Medicine,Hangzhou 310058,China;National Human Brain Bank for Development and Function,Department of Human Anatomy,Experimental Teaching Center,Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing 100005,China;Department of Human Anatomy,Human Brain Bank,Hebei Medical University,Shijiazhuang 050017,China;Department of Neurosurgery,Xuanwu Hospital,Capital Medical University,Beijing 100053,China;Department of Pathology,Xuanwu Hospital,Capital Medical University,Beijing 100053,China)

机构地区：[1]中国医学科学院基础医学研究所北京协和医学院人体解剖学与组织胚胎学系,国家发育和功能人脑组织资源库,北京100005 [2]国家健康与疾病人脑组织资源库,杭州310058 [3]浙江大学脑科学与脑医学学院,杭州310058 [4]中国医学科学院基础医学研究所北京协和医学院实验教学中心,国家发育和功能人脑组织资源库,北京100005 [5]河北医科大学人体解剖学教研室,人脑组织库,石家庄050017 [6]首都医科大学宣武医院神经外科,北京100053 [7]首都医科大学宣武医院病理科,北京100053

出　　处：《解剖学报》2024年第6期734-745,共12页Acta Anatomica Sinica

基　　金：科技创新2030-“脑科学与类脑研究”重大项目2021年度定向委托项目课题1(2021ZD0201100);中国医学科学院医学与健康科技创新工程项目(CIFMS-2021-I2M-1-025)。

摘　　要：人脑组织库是根据标准操作方案收集、处理和保存死亡后捐献者大脑和相关组织以及临床信息,并提供组织样本和数据以促进神经科学研究的资源库。人脑组织库是神经科学研究和神经疾病诊断的基础,保证人脑组织库样本质量标准化十分重要。中国人脑组织库(简称脑库)协作联盟标准化操作方案(SOP)第1版发布于2017年,脑库联盟成员日益增多,为确保提供脑组织样本的质量标准一致性,脑库联盟专家对第1版SOP进行了修订,以满足日益增长的神经科学研究需求。修订版SOP强调了伦理标准,增加了神经病理学评估脑区,并对脊髓取材和病理评估加以了说明。Human brain banks use a standardized protocol to collect,process and store post⁃mortem human brains and related tissues,along with relevant clinical information,and to provide the tissue samples and data as a resource to foster neuroscience research according to a standardized operating protocols(SOP).Human brain bank serves as the foundation for neuroscience research and the diagnosis of neurological disorders,highlighting the crucial rule of ensuring the consistency of standardized quality for brain tissue samples.The first version of SOP in 2017 was published by the China Human Brain Bank Consortium.As members increases from different regions in China,a revised SOP was drafted by experts from the China Human Brain Bank Consortium to meet the growing demands for neuroscience research.The revised SOP places a strong emphasis on ethical standards,incorporates neuropathological evaluation of brain regions,and provides clarity on spinal cord sampling and pathological assessment.Notable enhancements in this updated version of the SOP include reinforced ethical guidelines,inclusion of matching controls in recruitment,and expansion of brain regions to be sampled for neuropathological evaluation.

关 键 词：中国 人脑组织库 神经科学 标准化操作 

分 类 号：R322.81[医药卫生—人体解剖和组织胚胎学]