鱼类早期红细胞发育与抗逆性状形成的研究进展  

RESEARCH PROGRESS ON EARLY STAGES ERYTHROGENESIS AND STRESS RESISTANCE TRAITS FORMATION IN FISH

作　　者：陈慧可 沈铮 刘思遥 刘静霞[2] CHEN Hui-Ke;SHEN Zheng;LIU Si-Yao;LIU Jing-Xia(College of Life Science and Technology,Huazhong Agricultural University,Wuhan 430070,China;College of Fisheries,Huazhong Agricultural University,Wuhan 430070,China)

机构地区：[1]华中农业大学生命科学技术学院,武汉430070 [2]华中农业大学水产学院,武汉430070

出　　处：《水生生物学报》2024年第12期2133-2148,共16页Acta Hydrobiologica Sinica

基　　金：国家重点研发计划(2022YFF1000302);国家自然科学基金(32070807);国家重大项目(2023ZD04065);湖北省大学生创新创业训练计划(S202410504082)资助。

摘　　要：随着水产领域的设施化和高密度集约化养殖的发展,培育具有适应集约化养殖模式的耐低氧(抗非生物逆境)、抗病(抗生物逆境)、低应激等性状的鱼类新品种是解决水产养殖产业问题的关键。造血系统是维持鱼类正常生命活动最重要的系统之一,其中,红细胞参与鱼类氧气、营养物质运输和免疫防御应答等功能,在鱼类抗病和耐低氧过程中发挥重要调控作用。红细胞发育及其功能调控的分子元件是鱼类抗病抗逆性状形成的重要遗传基础。文章以鱼类红细胞发育为切入点,关注调控红细胞发育、成熟、功能的经典信号和分子,并从氧气运输和免疫防御应答两方面详细阐述了鱼类红细胞的生理功能,同时,关注鱼类在逆境胁迫下的红细胞发育及其功能调控的适应性机制。文章探讨了鱼类红细胞发育及其抗逆性状形成的遗传基础研究,鱼类逆境胁迫下的红细胞生成及其生理响应,为水产养殖动物抗逆新种质创制提供理论依据。The cultivation of new fish species with advantage traits,such as hypoxia tolerance(resistance to abiotic adversity),disease resistance(resistance to biotic adversity),and lower stress responses,is crucial for solving the problems in intensive aquaculture,particularly in facility-based and high-density systems.The hematopoietic system is crucial for maintaining the normal life activities of fish.Erythrocytes,which are involved in the transport of oxygen and nutrients as well as in the immune defense,play vital roles in regulating biological processes related to disease resistance and hypoxia tolerance.By focusing on erythrogenesis in fish,this review elaborates on the physiological functions of fish erythrocytes in terms of oxygen transport and immunity.It highlights the adaptive regulating mechanisms of erythrogenesis under adversity stresses,and focuses on the molecular mechanisms in regulating erythropoiesis.This review discusses the fundamental research on the genetic basis of stress resistance in fish,from the perspective of erythrogenesis development,providing important insights into the theoretical basis for creating new germplasm resources with enhanced stress resistance for aquaculture.

关 键 词：造血系统 红细胞发育 红细胞免疫 耐低氧 抗病 环境胁迫 抗逆育种 

分 类 号：S965.1[农业科学—水产养殖]