脓毒症并发急性呼吸窘迫综合征的研究进展  

Research progress on sepsis complicated with acute respiratory distress syndrome

作　　者：彭佐州 杨子建 石晓卉[1] PENG Zuozhou;YANG Zijian;SHI Xiaohui(Department of Cardiac Intensive Care Center,Cardiac and Panvascular Medicine Diagnosis and Treatment Center,People's Hospital of Xinjiang Uygur Autonomous Region,Urumqi,Xinjiang 830000,China)

机构地区：[1]新疆维吾尔自治区人民医院心脏及泛血管医学诊疗中心心脏重症科,新疆乌鲁木齐830000 [2]新疆医科大学研究生学院,新疆乌鲁木齐830000

出　　处：《中国临床研究》2024年第11期1659-1664,共6页Chinese Journal of Clinical Research

摘　　要：脓毒症是临床常见危重症,具有很高的死亡率。急性呼吸窘迫综合征(ARDS)是一种急性的肺部炎症性损伤疾病,是脓毒症发生发展过程中常见的并发症,可导致脓毒症患者的病死率显著增加。及时诊断和早期干预是改善ARDS患者预后的关键,但由于疾病的高度异质性,临床诊疗难以实现突破性进展,目前以较为保守的器官功能支持治疗为主,病死率仍居高不下。国际上提倡对脓毒症相关ARDS患者实行精准的个体化治疗,目前已对脓毒症相关ARDS的发病机制取得进步性发现,各种新型治疗手段为改善患者预后带来希望。本文对脓毒症相关ARDS的流行病学、发病机制、新型诊断及治疗干预措施进行综述。Sepsis is a clinically common critical illness with high mortality rate.Acute respiratory distress syndrome(ARDS),an acute inflammatory lung injury disease,is a common complication during the development of sepsis and can lead to a significant increase in the morbidity and mortality of sepsis patients.Timely diagnosis and early intervention are the keys to improving the prognosis of ARDS patients.However,due to the high heterogeneity of the disease,it is difficult to achieve breakthrough progress in clinical diagnosis and treatment.Currently,the main treatment is relatively conservative organ function support,but the mortality rate remains high.The international community advocates precise individualized treatment for sepsis-related ARDS patients,and progress has been made in understanding the pathogenesis of sepsis-related ARDS.Various new treatment methods have brought hope for improving the prognosis of patients.This article summarizes the epidemiology,pathogenesis,new diagnosis and treatment interventions of sepsis-related ARDS.

关 键 词：脓毒症 急性肺损伤 急性呼吸窘迫综合征 发病机制 内皮损伤 免疫功能紊乱 细胞死亡 线粒体功能障碍 感染 个体化治疗 

分 类 号：R631[医药卫生—外科学]