氟伐他汀联合重组人脑利钠肽对慢性心力衰竭患者脂肪细胞因子及血清miR-223、miR-101a的影响  

Effects of Fluvastatin Combined with Recombinant Human Brain Natriuretic Peptide on Adipocytes and Serum miR-223 and miR-101a in Patients with Chronic Heart Failure

作　　者：刘瑞卿[1] 董佩霞 牛少琼 王素娟[1] 郭莎莎[1] LIU Ruiqing;DONG Peixia;NIU Shaoqiong;WANG Sujuan;GUO Shasha(Department of Cardiology,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,China)

机构地区：[1]河南科技大学第一附属医院心血管内科,河南洛阳471000

出　　处：《河南医学研究》2024年第22期4157-4161,共5页Henan Medical Research

摘　　要：目的探讨氟伐他汀联合重组人脑利钠肽对慢性心力衰竭(CHF)患者脂肪细胞因子及血清miR-223、miR-101a的影响。方法选取2021年3月至2023年3月在河南科技大学第一附属医院诊治的82例CHF患者,随机分为两组,对照组41例和研究组41例,两组接受常规基础治疗,对照组接受氟伐他汀治疗,观察组接受重组人脑利钠肽+氟伐他汀治疗,比较两组治疗前后的脂肪细胞因子及血清miR-223、miR-101a,临床治疗效果和不良反应发生情况。结果治疗后,两组网膜素、内脏脂肪组织源性丝氨酸蛋白酶抑制剂(vaspin)、脂肪素(apelin)较治疗前均升高,趋化素较治疗前降低(P<0.05),且研究组网膜素、vaspin、apelin高于对照组,趋化素低于对照组(P<0.05)。治疗后,两组血清miR-101a较治疗前均升高,血清miR-223较治疗前降低(P<0.05),且研究组血清miR-101a高于对照组,血清miR-223低于对照组(P<0.05)。研究组临床治疗总有效率为95.12%,高于对照组的70.73%(P<0.05)。研究组不良反应发生率为17.07%,与对照组的9.76%比较,差异无统计学意义(P>0.05)。结论氟伐他汀联合重组人脑利钠肽治疗CHF患者,可有效提高网膜素、vaspin、apelin和血清miR-101a,降低趋化素和血清miR-223,提高临床治疗效果,且不会增加不良反应。Objective To investigate the effects of fluvastatin combined with recombinant human brain natriuretic peptide(rhBNP)on adipocytokines and serum miR-223 and miR-101a in patients with chronic heart failure(CHF).Methods Eighty-two patients with CHF diagnosed and treated in the First Affiliated Hospital of Henan University of Science and Technology from March 2021 to March 2023 were randomly divided into two groups,the control group(41 cases)and the study group(41 cases).Two groups gave conventional basic treatment,the control group underwent recombinant human brain natriuretic peptide treatment,the study group received recombinant human brain natriuretic peptide and fluvastatin treatment.The adipocytokines,serum miR-223 and miR-101a,the clinical therapeutic effect and the occurrence of adverse reactions were compared between the two groups before and after treatment.Results After treatment,omentin,visceral adipose tissue-derived serine protease inhibitor(vaspin)and adiponectin(apelin)in both groups were higher than those before treatment,chemerin in both groups were lower than those before treatment(P<0.05),and omentin,vaspin and apelin in the study group were higher than those in the control group,and chemerin in the study group was lower than that in the control group.After treatment,the serum miR-101a in both groups increased and the serum miR-223 in both groups decreased(P<0.05),and the serum miR-101a in the study group was higher than that in the control group,the serum miR-223 in the study group was lower than that in the control group(P<0.05).The total effective rate of the study group was 95.12%,which was higher than that of the control group(P<0.05).The incidence of adverse reactions in the study group was 17.07%,which was not significantly different from 9.76%in the control group(P>0.05).Conclusion Fluvastatin combined with recombinant human brain natriuretic peptide can effectively increase omentin,vaspin,apelin and serum miR-101a,decrease chemerin and serum miR-223,and improve the clinical efficacy witho

关 键 词：慢性心力衰竭 氟伐他汀 重组人脑利钠肽 临床效果 脂肪细胞因子 

分 类 号：R541.6[医药卫生—心血管疾病]