开心逍遥汤联合沙库巴曲缬沙坦治疗慢性心力衰竭合并高血压的临床效果  

Clinical Effect of Kaixin Xiaoyao Decoction and Sacubitril Alsartan in the Treatment of Chronic Heart Failure Complicated with Hypertension

作　　者：吴松林 WU Songlin(Heart Disease Zone 1,Zhumadian Traditional Chinese Medicine Hospital,Zhumadian 463000,China)

机构地区：[1]驻马店市中医院心病一区,河南驻马店463000

出　　处：《河南医学研究》2024年第22期4168-4171,共4页Henan Medical Research

摘　　要：目的探讨开心逍遥汤联合沙库巴曲缬沙坦治疗慢性心力衰竭(CHF)合并高血压患者的临床效果。方法选取2022年2月至2023年12月驻马店市中医院收治的CHF合并高血压患者共计75例,以随机数字表法分成研究组(37例)与对照组(38例),对照组接受沙库巴曲缬沙坦治疗,研究组接受开心逍遥汤联合沙库巴曲缬沙坦治疗,比较两组临床疗效、血压水平、心功能、心肌损伤指标。结果研究组治疗总有效率(86.49%)较对照组(65.79%)更高(P<0.05);两组治疗后收缩压(SBP)、舒张压(DBP)水平下降(P<0.05),研究组较对照组更低(P<0.05);两组治疗后左室射血分数(LVEF)、心排血量(SV)升高(P<0.05),左心室质量指数(LVMI)下降(P<0.05),研究组LVEF、SV较对照组更高(P<0.05),LVMI更低(P<0.05);两组治疗后N末端B型脑钠肽前体(NT-proBNP)、肌钙蛋白(cTn)I、基质金属蛋白酶9(MMP-9)水平下降(P<0.05),研究组较对照组更低(P<0.05)。结论给予CHF合并高血压患者开心逍遥汤联合沙库巴曲缬沙坦治疗,能够提高临床效果,稳定血压水平,改善患者心功能及心肌损伤指标。Objective To explore the clinical efficacy of Kaixin Xiaoyao Decoction and sacubitril alsartan in the treatment of patients with CHF and hypertension.Methods A total of 75 patients with CHF complicated with hypertension who were admitted in Zhumadian Traditional Chinese Medicine Hospital from March 2022 to February 2023 were selected,and randomly divided into the study group(37 cases)and the control group(38 cases).The control group was treated with sacubitril alsartan,while the study group was treated with Kaixin Xiaoyao Decoction and sacubitril alsartan.The clinical efficacy,blood pressure levels,heart function,and myocardial injury indicators in both groups were compared.Results In comparison of the control group(65.79%),the total effective rate of the study group(86.49%)was higher(P<0.05).After treatment,the systolic blood pressure(SBP),diastolic blood pressure(DBP)levels in both groups were decreased(P<0.05),and in comparison of the control group,the study group was lower(P<0.05).After treatment,the left ventricular ejection fraction(LVEF),cardiac output(SV)in both groups were increased(P<0.05),left ventricular mass index(LVMI)were decreased(P<0.05),in comparison of the control group,the LVEF and SV of the study group was higher(P<0.05),the LVMI was lower(P<0.05).After treatment,the N-terminal B-type natriuretic peptide precursor(NT-proBNP),cardiac troponin(cTn)I,matrix metalloproteinase 9(MMP-9)in both groups were decreased(P<0.05),and in comparison of the control group,the study group was lower(P<0.05).Conclusion The treatment of patients with CHF and hypertension with Kaixin Xiaoyao Decoction and sacubitril alsartan can improve clinical efficacy,stabilize blood pressure levels,and improve patient cardiac function and myocardial injury indicators.

关 键 词：慢性心力衰竭 高血压 开心逍遥汤 沙库巴曲缬沙坦 

分 类 号：R541.6[医药卫生—心血管疾病]