牛碱性成纤维细胞生长因子联合脱细胞真皮基质修复深Ⅱ度烧伤创面的临床研究  

Clinical Study on Bovine Basic Fibroblast Growth Factor Combined with Acellular Dermal Matrix for Repairing Deep Second Degree Burn Wounds

作　　者：曹青 何霞飞 CAO Qing;HE Xiafei(Department of Burn Plastic and Wound Repair,Jiujiang NO.1 People's Hospital,Jiujiang 332000,China;不详)

机构地区：[1]九江市第一人民医院烧伤整形与创面修复科,江西九江332000

出　　处：《中国医学创新》2024年第28期1-6,共6页Medical Innovation of China

基　　金：江西省卫生健康委科技计划项目(202311456)。

摘　　要：目的:观察牛碱性成纤维细胞生长因子联合脱细胞真皮基质(ADM)修复深Ⅱ度烧伤创面的临床效果。方法:选取九江市第一人民医院2023年1—12月收治的深Ⅱ度烧伤患者120例,根据随机数字表法分为A组、B组、C组,各40例。A组清创后外涂牛碱性成纤维细胞生长因子凝胶并覆盖ADM,B组清创后直接覆盖ADM,C组清创后仅外用牛碱性成纤维细胞生长因子凝胶。比较三组创面情况(创面愈合、创面容积、后期手术率)、瘢痕情况[温哥华瘢痕量表(VSS)、色素沉着发生率]、炎症因子[白细胞(WBC)计数、超敏C反应蛋白(hs-CRP)、白细胞介素(IL)-6],并统计三组临床疗效、不良反应发生率。结果:创面完全愈合3个月后A组色素沉着发生率及治疗30 d后A组后期手术率均低于B组和C组,治疗7、14、21 d后创面容积均小于B组和C组,创面愈合均显著高于B组和C组(P<0.05);治疗21 d后,A组WBC、hs-CRP、IL-6水平均显著低于B组和C组(P<0.05);A组临床总有效率显著高于B组和C组(P<0.05);三组不良反应发生率比较,差异无统计学意义(χ^(2)=1.208,P=0.547)。结论:牛碱性成纤维细胞生长因子凝胶联合ADM修复深Ⅱ度烧伤创面的效果显著,对患者创面愈合、瘢痕情况、色素沉着及炎症因子均有积极改善作用,安全性较高。Objective:To observe the clinical effect of Bovine Basic Fibroblast Growth Factor combined with acellular dermal matrix(ADM)in repairing wound surface of deep second degree burn.Method:A total of 120 patients with deep second degree burn treated in Jiujiang NO.1 People's Hospital from January to December 2023 were selected and divided into group A,group B and group C according to random number table method,40 cases in each group.Group A was coated with Bovine Basic Fibroblast Growth Factor Gel and ADM after debridement,group B was directly covered with ADM after debridement,and group C only Bovine Basic Fibroblast Growth Factor Gel was external applied after debridement.The wound condition(wound healing,wound volume and later surgery rate),scar condition[Vancouver scar scale(VSS),incidence of pigmentation],inflammatory factors[white blood cell(WBC)count,hypersensitive C reactive protein(hs-CRP)and interleukin-6(IL-6)]of three groups were compared,and the clinical efficacy and incidence of adverse reactions were counted.Result:The wound healed completely after 3 months,the incidence of pigmentation in group A,and the later surgery rate after 30 days of treatment in group A were lower than those in group B and group C,the wound volume after 7,14 and 21 days of treatment were lower than those in group B and group C,and the wound healing were significantly higher than those in group B and group C(P<0.05).After 21 d of treatment,the levels of WBC,hs-CRP and IL-6 in group A were significantly lower than those in group B and group C(P<0.05).The total clinical effective rate of group A was significantly higher than that of group B and group C(P<0.05).There was no significant difference in the incidence of adverse reactions among three groups(字2=1.208,P=0.547).Conclusion:Bovine Basic Fibroblast Growth Factor Gel combined with ADM has a significant effect in repairing wound surface of deep second degree burn,and has positive improve effects on wound healing,scar condition,pigmentation and inflammatory factors of patients

关 键 词：牛碱性成纤维细胞生长因子凝胶 脱细胞真皮基质 深Ⅱ度烧伤 烧伤创面 瘢痕 炎症因子 

分 类 号：R644[医药卫生—外科学]