CTD相关ILD患者血清中HDAC3水平及临床意义  

Serum HDAC3 Levels in CTD Associated ILD Patients and Its Clinical Significance

作　　者：叶铮 姚娜 徐芳琳 YE Zheng;YAO Na;XU Fanglin(Department of Respiratory and Critical Care,Jiangxi Chest Hospital,Nanchang 330006,China;不详)

机构地区：[1]江西省胸科医院呼吸与危重症科,江西南昌330006

出　　处：《中国医学创新》2024年第28期149-152,共4页Medical Innovation of China

摘　　要：目的:探讨结缔组织疾病(CTD)相关间质性肺疾病(ILD)患者血清中组蛋白去乙酰化酶3(HDAC3)表达水平及临床意义。方法:选取2021年11月—2022年12月于江西省胸科医院住院治疗的40例CTD相关ILD患者作为CTD相关ILD组,选取同期接受体检的40例健康正常人为健康对照组。比较两组血常规指标[白细胞(WBC)、红细胞(RBC)、血小板(PLT)计数、血红蛋白(Hb)]、肾功能指标(肌酐、尿素氮、尿酸)、炎症指标[C反应蛋白(CRP)、白细胞介素-6(IL-6)]、血清HDAC3水平。结果:两组血常规指标和肾功能指标比较,差异均无统计学意义(P>0.05)。CTD相关ILD组血清CRP、IL-6及血清HDAC3水平均显著高于健康对照组(P<0.05)。Pearson相关系数分析显示,CTD相关ILD患者血清HDAC3水平与血常规及肾功能指标无显著相关性(P>0.05),与CRP、IL-6呈正相关(P<0.05)。结论:CTD相关ILD患者血清HDAC3水平高于健康人群,可能与患者炎症因子表达有关,在辅助诊断CTD相关ILD方面可能有一定的参考价值。Objective:To investigate the expression level of histone deacetylase 3(HDAC3)in serum of connective tissue disease(CTD)associated interstitial lung disease(ILD)and its clinical significance.Method:A total of 40 CTD associated ILD patients hospitalized in Jiangxi Chest Hospital from November 2021 to December 2022 were selected as CTD associated ILD group,and 40 healthy normal patients who underwent physical examination during the same period were selected as healthy control group.Blood routine indexes[white blood cell(WBC),red blood cell(RBC),platelet(PLT)count,hemoglobin(Hb)],renal function indexes(creatinine,urea nitrogen,uric acid),inflammatory indexes[C reactive protein(CRP),interleukin-6(IL-6)]and serum HDAC3 levels were compared between two groups.Result:There were no significant differences in blood routine indexes and renal function indexes between two groups(P>0.05).The levels of CRP,IL-6 and HDAC3 in CTD associated ILD group were significantly higher than those in healthy control group(P<0.05).Pearson correlation coefficient analysis showed that serum HDAC3 level in CTD associated ILD patients had no significant correlation with blood routine and renal function indexes(P>0.05),but was positively correlated with CRP and IL-6(P<0.05).Conclusion:Serum HDAC3 level in CTD associated ILD patients is higher than that in healthy population,which may be related to the expression of inflammatory factors in the patients,and may have certain reference value in assisting the diagnosis of CTD associated ILD.

关 键 词：结缔组织病 肺间质病变 组蛋白去乙酰化酶3 

分 类 号：R593.2[医药卫生—内科学]