连续性血液净化治疗对老年慢性肾衰竭患者肾功能及机体炎症反应的影响  

Effect of Continuous Blood Purification Therapy on Renal Function and Body Inflammatory Response of Elderly Chronic Renal Failure Patients

作　　者：邱敏姿 吴春瑶 陈艳霞[1] 徐承云[1] QIU Minzi;WU Chunyao;CHEN Yanxia;XU Chengyun(Department of Nephrology,the Second Affiliated Hospital of Nanchang University,Nanchang 330000,China;不详)

机构地区：[1]南昌大学第二附属医院肾内科,江西南昌330000

出　　处：《中国医学创新》2024年第30期60-64,共5页Medical Innovation of China

摘　　要：目的:探讨连续性血液净化治疗对老年慢性肾衰竭(CRF)患者肾功能及机体炎症反应的影响。方法:选取南昌大学第二附属医院肾内科2023年1月—2024年5月收治的老年CRF患者97例,采用随机数字表法分为连续性静脉-静脉血液滤过(CVVH)组(50例)、间断性血液透析(IHD)组(47例)。CVVH组采用连续性血液净化治疗,IHD组采用间断性血液净化治疗。对比两组治疗效果、治疗前后肾功能、炎症反应,并记录并发症情况。结果:治疗后IHD组、CVVH组肌酐(Cr)、尿素氮(BUN)水平较治疗前均降低,同IHD组对比,CVVH组Cr、BUN水平均更低(P<0.05)。治疗后IHD组、CVVH组炎症因子水平较治疗前均降低,同IHD组对比,CVVH组肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、白细胞介素-6(IL-6)水平均更低(P<0.05)。CVVH组总有效率为92.00%(46/50),IHD组总有效率为70.21%(33/47),CVVH组显著高于IHD组(P<0.05)。CVVH组并发症发生率为28.00%(14/50),IHD组并发症发生率为63.83%(30/47),CVVH组显著低于IHD组(P<0.05)。结论:CVVH治疗CRF效果更佳,可有效改善患者肾功能,减轻机体炎症反应,且能减少并发症的发生。Objective:To explore the effects of continuous blood purification therapy on renal function and body inflammatory response in elderly chronic renal failure(CRF)patients.Method:Ninety-seven cases of elderly CRF patients admitted to the Department of Nephrology of the Second Affiliated Hospital of Nanchang University from January 2023 to May 2024 were selected and were divided into the continuous veno-venous hemofiltration(CVVH)group(50 cases)and the intermittent hemodialysis(IHD)group(47 cases)by the method of randomized number table.The CVVH group was treated with continuous blood purification,and the IHD group was treated with intermittent blood purification.The treatment effect,renal function,inflammatory response before and after treatment of the two groups were compared,and the complications was recorded.Result:After treatment,Cr and BUN levels in IHD group and CVVH group were lower than those before treatment,and compared with IHD group,the levels of creatinine(Cr)and urea nitrogen(BUN)in CVVH group were lower(P<0.05).After treatment,the levels of inflammatory factors in IHD group and CVVH group were lower than those before treatment,and the levels of tumor necrosis factor-α(TNF-α),C reactive protein(CRP)and interleukin-6(IL-6)were lower in CVVH group compared with IHD group(P<0.05).The total effective rate was 92.00%(46/50)in CVVH group and 70.21%(33/47)in IHD group,that in CVVH group was significantly higher than that of IHD group(P<0.05).The complication rate was 28.00%(14/50)in CVVH group and 63.83%(30/47)in IHD group,that in CVVH group was significantly lower than that in IHD group(P<0.05).Conclusion:CVVH is more effective in the treatment of CRF,can effectively improve the renal function of patients,reduce the inflammatory response of the body,and can reduce the occurrence of complications.

关 键 词：老年 慢性肾衰竭 连续性血液净化 肾功能 炎症 

分 类 号：R692.5[医药卫生—泌尿科学]