成人支气管哮喘发作期患者中医证型特点及与miR-155-5p、Treg/Th17细胞平衡的关系  

The characteristics of TCM syndromes in adult patients with bronchial asthma attack and their relationship with miR-155-5p andTreg/Th17cell balance

作　　者：魏挺[1] 彭宇[2] 姚纲 WEI Ting;PENG Yu;YAO Gang(Department of Internal Medicine,Xi an Jiaotong University Hospital,Xi an Shaanxi 710049,China;Department of Rehabilitation,The First Affiliated Hospital of Xi an Jiaotong University,Xi an Shaanxi 719000,China;The forth Department of Internal Medicine,Fengxiang Traditional Chinese Medicine Hospital,Baoji Shaanxi 721400,China)

机构地区：[1]西安交通大学医院内科,陕西西安710049 [2]西安交通大学第一附属医院康复科,陕西西安710061 [3]宝鸡市凤翔区中医医院内四科,陕西宝鸡721400

出　　处：《四川中医》2024年第11期17-20,共4页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:探讨成人支气管哮喘发作期患者中医证型特点及与miR-155-5p、Treg/Th17细胞平衡的关系。方法:选择2022年3月~2024年2月在我院及我院上级医联体医院就诊的成人支气管哮喘发作期患者116例作为研究对象。收集患者一般资料、miR-155-5p mRNA、Treg/Th17及相关细胞因子[白细胞介素(IL)-17、IL-23]指标,同时对患者进行中医辨证分型,比较不同中医证型患者一般资料、miR-155-5p、Treg/Th17、IL-17、IL-23水平。结果:116例成人支气管哮喘发作期患者中医辨证为热哮、风哮、冷哮、虚哮,占比分别为34.48%(40/116),31.90%(37/116),22.41%(26/116),11.21%(13/116)。其中虚哮者年龄均高于风哮、热哮、冷哮者(P<0.05),其余证型年龄无差异(P>0.05)。不同中医证型患者病程、肺功能指标无差异(P>0.05)。不同中医证型患者miR-155-5p mRNA、Treg/Th17、IL-17、IL-23水平比较有差异(P<0.05),且风哮>冷哮>热哮>虚哮(P<0.05)。结论:成人支气管哮喘发作期以热哮、风哮为主,风哮患者miR-155-5p水平升高,Treg/Th17失衡,两者可能作为成人支气管哮喘发作期证型客观化的指标之一。Objective:To explore the characteristics of TCM syndromes in adult patients with bronchial asthma and its relationship with miR-155-5p and Treg/Th17cell balance.Methods:A total of 116adult patients with bronchial asthma who were treated in our hospital and our superior medical consortium hospital from March 2022to February 2024were selected as subjects.The general data of patients,miR-155-5p mRNA,Treg/Th17and related cytokines[interleukin(IL)-17,IL-23]were collected.At the same time,the patients were classified according to TCM syndrome differentiation,and the general data,miR-155-5p,Treg/Th17,IL-17and IL-23levels of patients with different TCM syndromes were compared.Results:The TCM syndromes of 116adult patients with bronchial asthma attack were heat asthma,wind asthma,cold asthma and deficiency asthma,accounting for 34.48%(40/116),31.90%(37/116),22.41%(26/116)and 11.21%(13/116),respectively.Among them,the age of deficiency asthma was higher than that of wind asthma,heat asthma and cold asthma(P<0.05).There was no difference in the course of disease and pulmonary function indexes between patients with different TCM syndromes(P>0.05).There were differences in the levels of miR-155-5p mRNA,Treg/Th17,IL-17and IL-23in patients with different TCM syndromes(P cold asthma>heat asthma>deficiency asthma)(P<0.05).Conclusion:The attack stage of bronchial asthma in adults is dominated by heat asthma and wind asthma.The level of miR-155-5p in patients with wind asthma is increased,and Treg/Th17is imbalanced.Both of them may be used as one of the objective indicators of syndrome type in the attack stage of bronchial asthma in adults.

关 键 词：支气管哮喘 发作期 中医证型特点 miR-155-5p Treg/Th17细胞平衡 

分 类 号：R562.25[医药卫生—呼吸系统]