金翘消瘿方加减治疗亚急性甲状腺炎(外感热毒证)疗效观察  

Observation on effects of modified Jinqiao Xiaoying decoction in the treatment of subacute thyroiditis(exogenous heat toxin syndrome)

作　　者：胡海鹰 庾利 HU Haiying;YU Li(Health Management Center of West China Hospital,Chengdu Sichuan 610200,China)

机构地区：[1]四川大学华西医院健康管理中心,四川成都610200

出　　处：《四川中医》2024年第11期76-79,共4页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:探究金翘消瘿方加减治疗亚急性甲状腺炎(外感热毒证)的效果。方法:92例亚急性甲状腺炎外感热毒证患者随机分为对照组和联合组各46例。对照组口服醋酸泼尼松片治疗,联合组口服醋酸泼尼松片治疗的同时采用金翘消瘿方加减内服治疗,两组患者急性期疗程均为14d。比较两组患者疗效差异、急性期症状改善时间,治疗前后均检测甲状腺功能指标[游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)]、红细胞沉降率(ESR)及炎症因子[高敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平进行比较,统计并计算不良反应率及随访3个月的复发率。结果:联合组治疗总有效率为91.30%,较对照组的76.09%显著更高( P <0.05);联合组患者退热、疼痛消退、消肿的急性期症状改善时间较对照组显著缩短( P <0.05);联合组患者治疗后的FT3、FT4、ESR及炎症因子(hs-CRP、IL-6、TNF-α)水平均较对照组显著缩短( P <0.05),TSH水平较对照组显著升高( P <0.05);比较两组用药期间的不良反应发生率差异无统计学意义( P >0.05)。治疗后随访3个月均无失访,联合组的复发率2.17%,较对照组13.04%显著更低( P <0.05)。结论:金翘消瘿方加减治疗亚急性甲状腺炎(外感热毒证)疗效显著,有利于临床症状的迅速缓解、甲状腺功能和ESR的恢复及机体炎症的改善,安全性好且复发率低。Objective: To explore the effects of modified Jinqiao Xiaoying decoction on subacute thyroiditis of exogenous heat toxin syndrome. Methods: 92patients with subacute thyroiditis of exogenous heat toxin syndrome were randomly divided into control group(46cases) and combined group(46cases). The control group was treated with oral prednisone acetate tablets while the combined group was given oral administration of prednisone acetate tablets and modified Jinqiao Xiaoying decoction. The efficacy and improvement times of symptoms in acute stage, thyroid function indicators [free triiodothyronine(FT3), free thyroxine(FT4), thyroid stimulating hormone(TSH)], erythrocyte sedimentation rate(ESR) and inflammatory factors [high-sensitivity C-reactive protein(hs-CRP), interleukin-6(IL-6), tumor necrosis factor-α(TNF-α)] before and after treatment were compared between the two groups. The adverse reaction rate and recurrence rate after 3months of follow-up were counted and calculated. Results: The total effective rate of treatment in combined group(91.30%) was significantly higher than that in control group(76.09%)( P <0.05). Compared with control group, the fever abatement time, pain subsidence time and swelling subsidence time were significantly shorter in combined group( P <0.05). The levels of FT3, FT4, ESR, hs-CRP, IL-6and TNF-α in combined group after treatment were significantly reduced( P <0.05), while the level of TSH was significantly enhanced compared to control group( P <0.05). There were no statistical differences in the incidence rates of adverse reactions between the two groups during medication( P >0.05). The recurrence rate in combined group was 2.17% during 3-month follow-up after treatment, which was obviously lower than 13.04% in control group( P <0.05). Conclusion: Modified Jinqiao Xiaoying decoction has a significant efficacy in treating subacute thyroiditis with exogenous heat toxin syndrome, and it can quickly relieve the clinical symptoms, promote the recovery of thyroid function and ESR, and relieve

关 键 词：金翘消瘿方加减 亚急性甲状腺炎 外感毒热证 疗效 

分 类 号：R581.4[医药卫生—内分泌]