左氧氟沙星联合头孢唑林治疗妊娠期高血压疾病产妇产褥期感染的疗效  

Effect of levofloxacin combined with cefazolin on treatment of puerpera with hypertensive disorders of pregnancy and puerperal infection

作　　者：王彦云 孟文珊 刘鹏妹 潘永昕 张艳杰[1] WANG Yan-yun;MENG Wen-shan;LIU Peng-mei;PAN Yong-xin;ZHANG Yan-jie(Baotou Medical College,Baotou,Inner Mongolia O1400O,China;不详)

机构地区：[1]包头医学院卫生健康学院,内蒙古包头014000 [2]包头医学院第一附属医院血液内科,内蒙古包头014000

出　　处：《中华医院感染学杂志》2024年第21期3336-3340,共5页Chinese Journal of Nosocomiology

基　　金：内蒙古自治区教育科学研究“十四五”规划基金资助项目(NZJGH2023002)。

摘　　要：目的探讨左氧氟沙星联合头孢唑林治疗妊娠期高血压疾病(HDP)产妇产褥期感染的疗效。方法选取包头医学院第一附属医院2021年1月-2024年1月收治的120例HDP产褥期感染产妇为研究对象,随机分为研究组和对照组,各60例。对照组给予头孢唑林治疗,研究组给予左氧氟沙星联合头孢唑林治疗,比较两组细菌清除率、治疗有效率、不良反应发生率及治疗3 d后辅助性T细胞17(Th17)/调节性T细胞(Treg)细胞比例和相关细胞因子水平。结果研究组产妇细菌清除率高于对照组(P<0.05);研究组产妇治疗疗效率高于对照组(P<0.05);两组产妇不良反应发生率比较,无统计学差异;治疗3 d后,研究组产妇Th17、Th17/Treg、白细胞介素(IL)-17、IL-22、降钙素原(PCT)、IL-6低于治疗前及对照组,Treg、IL-10、转化生长因子-β1(TGF-β1)高于治疗前及对照组(P<0.05)。结论左氧氟沙星联合头孢唑林治疗HDP产褥期感染可以提高产妇治疗效果,维持Th17/Treg细胞免疫平衡,降低血清PCT、IL-6水平,且不会增加产妇不良反应。OBJECTIVE To explore the effect of levofloxacin combined with cefazolin on treatment of the puerpera with hypertensive disorders of pregnancy(HDP)and puerperal infection.METHODS A total of 120 HDP puerpera with puerperal infection who were treated in the First Affiliated Hospital of Baotou Medical College from Jan.2021 to Jan.2024 were recruited as the research subjects and were randomly divided into the study group and the control group,with 60 cases in each group.The control group was treated with cefazolin,and the study group was given levofloxacin combined with cefazolin.The eradication rate of bacteria,effective rate of treatment and incidence of adverse reactions were compared between the two groups;the helper T cell 17(Th17)/regulator T cell(Treg)ratio and levels of related cytokines were compared between the two groups after the treatment for 3 days.RESULTS The eradication rate of bacteria was higher in the study group than in the control group(P<0.05).The effective rate of treatment of the study group was higher than that of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups of puerpera.The Th17,Th17/Treg ratio,interleukin(IL)-17,IL-22,procalcitonin(PCT)and IL-6 were lower after the treatment for 3 days than before the treatment,and the above indexes of the study group were lower than those of the control group;the Treg,IL-10 and transforming growth factor-β1(TGF-β1)were higher after the treatment for 3 days than before the treatment,and the above indexes of the study group were higher than those of the control group(P<0.05).CONCLUSION Levofloxacin combined with cefazolin can achieve remarkable effect on treatment of the HDP puerpera with puerperal infection,maintain the immunologic balance of Th17/Treg cells and reduce the levels of serum PCT and IL-6 without increasing the adverse reactions.

关 键 词：左氧氟沙星 头孢唑林 产褥期感染 妊娠期高血压疾病 辅助性T细胞17/调节性T细胞 

分 类 号：R714.246[医药卫生—妇产科学]