外周血STAT3、NLRP3、TLR4表达对儿童肺炎支原体肺炎疾病进展的预测价值  

Values of peripheral blood STAT3,NLRP3 and TLR4 in prediction of disease progression of children with Mycoplasma pneumoniae pneumoniae

作　　者：豆吉娟[1] 刘月影[1] 贾红亮 朱炜杰[1] 曹亚船[1] DOU Ji-juan;LIU Yue-ying;JIA Hong-liang;ZHU Wei-jie;CAO Ya-chuan(Jiangnan University Affiliated Hospital,Wuri,Jiangsu 214122,China)

机构地区：[1]江南大学附属医院儿科,江苏无锡214122

出　　处：《中华医院感染学杂志》2024年第21期3351-3355,共5页Chinese Journal of Nosocomiology

基　　金：国家自然科学基金面上基金资助项目(82371462)。

摘　　要：目的分析外周血信号转导子和转录激活子3(STAT3)、NOD样受体蛋白3(NLRP3)、Toll样受体4(TLR4)表达对儿童肺炎支原体肺炎(MPP)疾病进展的预测价值。方法于2022年10月-2023年10月从江南大学附属医院随机选择110例MPP患儿为MPP组,根据病情严重程度分为轻症组71例和重症组39例,同期从医院随机选择112例感染但非MPP患儿为非MPP组,另外随机选取同期于医院进行体检的120名健康儿童为对照组。比较MPP组、非MPP组和对照组,重症组和轻症组外周血STAT3、NLRP3、TLR4水平,并将重症组纳入阳性,轻症组纳入阴性,绘制受试者工作特征(ROC)曲线获取曲线下面积(AUC),分析外周血STAT3、NLRP3、TLR4对MPP患儿疾病进展的预测价值。结果MPP组、非MPP组外周血STAT3、NLRP3、TLR4水平高于对照组(P<0.05)。重症组外周血STAT3、NLRP3、TLR4水平高于轻症组(P<0.05)。ROC分析结果显示,外周血STAT3、NLRP3、TLR4联合检测预测MPP患儿疾病进展的AUC值为0.928,高于三者单一检测(P<0.05)。结论MPP患儿外周血STAT3、NLRP3、TLR4呈高表达,三者可参与患儿疾病进展过程,且三者联合检测对MPP患儿疾病进展的预测价值更高。OBJECTIVE To analyze the values of peripheral blood signal transducer and activator of transcription 3(STAT3),NOD-like receptor protein 3(NLRP3)and Toll-like receptor 4(TLR4)in prediction of disease progression of the children with Mycoplasma pneumoniae pneumonia(MPP).METHODS A total of 110 children with MPP who were treated in Jiangnan University Affiliated Hospital from Oct.2022 to Oct.2023 were assigned as the MPP group and were divided into the mild group with 71 cases and the severe group with 39 cases according to the illness condition.Meanwhile,112 children who had infection but did not have MPP were chosen as the non-MPP group,120 healthy children who received physical examination were assigned as the control group.The levels of peripheral blood STAT3,NLRP3 and TLR4 were compared among the MPP group,the non-MPP group and the control group as well as between the severe group and the mild group.The severe group was included as the positive,and the mild group was included as the negative.Receiver operating characteristic(ROC)curves were drawn to obtain the areas under the curves(AUCs),and the values of the peripheral blood STAT3,NLRP3 and TLR4 in prediction of the disease progression of the MPP children were analyzed.RESULTS The levels of peripheral blood STAT3,NLRP3 and TLR4 of the MPP group and the non-MPP group were significantly higher than those of the control group(P<0.05).The levels of peripheral blood STAT3,NLRP3 and TLR4 of the severe group were significantly higher than those of the mild group(P<0.05).The result of ROC analysis showed that the AUC of the joint detection of peripheral blood STAT3,NLRP3 and TLR4 was 0.928 in prediction of the disease progression of the MPP children,significantly higher than that of the single detection(P<0.05).CONCLUSIONS The children with MPP show the high expressions of peripheral blood STAT3,NLRP3 and TLR4,which can participate the process of disease progression.The joint detection of the three indexes has higher value in prediction of the disease progression of t

关 键 词：儿童肺炎支原体肺炎 信号转导子和转录激活子3 NOD样受体蛋白3 Toll样受体4 疾病进展 重症肺炎 

分 类 号：R725.6[医药卫生—儿科]