美沙拉嗪联合肠道益生菌治疗溃疡性结肠炎疗效观察  

Clinical Efficacy of Mesalazine Combined with Probiotics in the Treatment of Ulcerative Colitis

作　　者：杜新菊 丁吉芳 DU Xinju;DING Jifang(Zhangdian District People's Hospital of Zibo,Zibo,Shandong,China 255000)

机构地区：[1]山东省淄博市张店区人民医院,山东淄博255000

出　　处：《中国药业》2024年第S02期47-49,共3页China Pharmaceuticals

摘　　要：目的探讨美沙拉嗪联合肠道益生菌(EM)治疗溃疡性结肠炎(UC)的临床疗效。方法选取医院2018年1月至2023年6月收治的UC患者45例,按治疗方案的不同分为联合组(25例)和单一组(20例),单一组患者予美沙拉嗪颗粒,联合组在单一组基础上联用肠道EM。比较两组的临床疗效、炎症物质水平、不良反应、各项症状消除用时等指标。结果与治疗前相比,两组患者治疗后的降钙素原(PCT)、C反应蛋白(CRP)等指标均显著降低,且联合组降低更显著(P<0.05)。联合组患者的不良反应发生率略低于单一组,但无显著差异(P>0.05);联合组患者的临床疗效显著高于单一组(P<0.05),腹泻症状、大便性状、腹痛症状、黏液脓血便症状等用时显著短于单一组(P<0.05)。结论美沙拉嗪联合肠道EM治疗UC的临床疗效良好,且不良反应较少。Objective To investigate the clinical efficacy of mesalazine combined with probiotics(EM)in the treatment of ulcerative colitis(UC).Methods A total of 45 patients with UC admitted to the hospital from January 2018 to June 2023 were selected and divided into the combination group(25 cases)and the single group(20 cases)according to different treatment plans.Patients in the single group were given mesalazine granules,while those in the combination group were given intestinal EM on the the single group.The clinical efficacy,levels of inflammatory substances,adverse reactions,and time taken to eliminate various symptoms between the two groups were compared.Results Compared with those before treatment,the procalcitonin(PCT)and C-reactive protein(CRP)after treatment in the two groups were significantly lower those before treatment,and those in the combined group were significant lower those in the single group(P<0.05).The incidence of adverse reactions in the combined group was slightly lower than that in the single group,but there was no significant difference(P>0.05).The clinical efficacy in the combined group was significantly higher than that in the single group(P<0.05),and the duration of symptoms such as diarrhea,stool consistency,abdominal pain,and mucous purulent bloody stool in the combined group was significantly shorter than that in the single group(P<0.05).Conclusion Mesalazine combined with intestinal EM in the treatment of UC has good clinical efficacy with relatively few adverse reactions.

关 键 词：肠道益生菌 美沙拉嗪 溃疡性结肠炎 临床疗效 药品不良反应 

分 类 号：R969.4[医药卫生—药理学] R975[医药卫生—药学]